A high-affinity human TCR-like antibody detects celiac disease gluten peptide–MHC complexes and inhibits T cell activation sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.
May 5, 2021
Therapeutic drug monitoring, half-dosing may not be ready for prime-time
Therapeutic drug monitoring (TDM) for patients with immune-mediated inflammatory diseases did not lead to better clinical remission rates, while routine dose reduction of anti-rheumatic drugs for patients with rheumatoid arthritis (RA) in remission offered modest benefits, according to two Norwegian trials.
In the NOR-DRUM Part A trial, clinical remission at week 30 was achieved in 50.5% of 198 patients with TDM versus 53% of 200 patients in the standard therapy group, for an adjusted difference of 1.5% (95% CI −8.2% to 11.1%,
P=0.78), reported Silje Watterdal Syversen, MD, PhD, of Diakonhjemmet Hospital in Oslo, and co-authors.
In the ARCTIC REWIND trial, disease flare occurred in 25% of 77 patients in the half-dose conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) group versus 6% in the stable-dose csDMARD group for a risk difference of 18% (95% CI 7%-29%), reported Si
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Senior Consultant combined with Adjunct Professor/ Associate Professor (20 %) in medicine (Orthopaedic Surgery)
Lovisenberg Diaconal Sykehus AS (LDS) is a hospital for approximately 200,000 inhabitants in Oslo in the field of internal medicine and mental health care. Furthermore the hospital has extensive elective surgery activity with 9000 operations per year in the field of orthopaedic, ENT and General surgery. The hospital is owned by the diaconal foundations Diakonova and Diakonissehuset Lovisenberg, and has an operating agreement with South-Eastern Norway Regional Health Authority (HSØ RHF). The hospital is based on diaconal values with non-commercial purposes. You as an employee are expected to actively contribute to our core values of quality and charity. See www.lds.no
Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.