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New experimental model simulates the blood-brain barrier


New experimental model simulates the blood-brain barrier
Using an experimental model to simulate the blood-brain barrier, scientists in Sweden reported in unprecedented detail how antioxidants protect the brain from inflammation caused by neurodegenerative diseases such as Alzheimer s and Parkinson s.
The study, conducted as a proof of concept by brain model developers at KTH Royal Institute of Technology in Stockholm, showed in minute-by-minute detail how the blood-brain barrier reacts to high levels of inflammation after the administration of a next-generation derivative of the widely-used anti-inflammatory drug, NAC (N-acetylcysteine).
The testing of NACA (N-Acetylcysteine Amide) for the first time with human stem cell-derived cells showed that the breakdown of the barrier under high loads of inflammation is actually more complex than we thought. ....

Thomas Winkler , Isabelle Matthiesen , Emily Henderson , Royal Institute Of Technology , N Acetylcysteine Amide , தாமஸ் விங்க்லர் , எமிலி ஹென்டர்சன் , அரச நிறுவனம் ஆஃப் தொழில்நுட்பம் ,