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Shingrix Approved to Prevent Shingles in Immunocompromised Adults Credit: GlaxoSmithKline. The Food and Drug Administration (FDA) has approved Shingrix (zoster vaccine recombinant, adjuvanted) for the prevention of herpes zoster (shingles) in adults 18 years of age and older who are or who will be at increased risk of herpes zoster due to immunodeficiency or immunosuppression caused by known disease or therapy. Previously, the vaccine was only approved for adults 50 years of age and older. The approval was based on data from clinical studies that assessed the efficacy and safety of Shingrix in adults 18 years of age and older who previously had an autologous hematopoietic stem cell transplant (auHSCT; N=1721) and in those undergoing treatment for hematologic malignancies (N=515; post-hoc analysis). ....