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Merck Advances ATR Inhibitor Berzosertib in Small Cell Lung Cancer With New Published Data and Initiation of Phase II Trial With Registrational Intent 1 A new company-sponsored, global clinical trial will further assess berzosertib in small cell lung cancer Merck is leading more than ten clinical trials across DNA Damage Response (DDR) pathways in various tumor types Merck, a leading science and technology company, today announced key clinical advancements for berzosertib (M6620), an investigational, potent and selective ataxia telangiectasia and Rad3-related (ATR) inhibitor. Berzosertib is the leading asset in the company s DNA damage response (DDR) inhibitor program and one of the most advanced ATR inhibitors in oncology clinical development industry-wide. ....
(0) - Inhibition of hyperactive RAS network signaling is nine times more effective with gedatolisib than with a PI3K-α inhibitor - - Synergistic cooperation between PI3K/mTOR and BCL signaling detected, suggesting potential patient benefit of combining gedatolisib with a BCL inhibitor - MINNEAPOLIS, MN / ACCESSWIRE / April 12, 2021 / Celcuity Inc. (NASDAQ:CELC), a clinical-stage biotechnology company pursuing an integrated companion diagnostic (CDx) and therapeutic strategy for treating patients with cancer, presented results of studies evaluating gedatolisib (a pan-PI3K/mTOR inhibitor), inavolisib (a PI3K- α inhibitor), and navitoclax (a BCL inhibitor) in breast and ovarian patient tumors. Results were presented in two e-posters at the American Association for Cancer Research (AACR) Annual Meeting. ....
Cholangiocarcinoma Pipeline Insight: Therapeutic analysis of 70+ pipeline therapies and 70+ pharmaceutical companies yahoo.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from yahoo.com Daily Mail and Mail on Sunday newspapers.
(1) The phase IIa proof-of-concept findings from ViiV Healthcare s innovative early pipeline of medicines show the antiviral activity, safety and tolerability of GSK 254 and support its continued study in phase IIb ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Pfizer Inc. and Shionogi Limited as shareholders, presented positive data from its phase IIa proof-of-concept study of the investigational maturation inhibitor GSK3640254 (GSK 254). The study showed the antiviral activity of GSK 254, establishing a relationship between dose and antiviral response, with the 140 mg and 200 mg doses showing the greatest reduction in plasma HIV-1 RNA. These findings were presented today at the (virtual) 2021 Conference on Retroviruses and Opportunistic Infections (CROI). ....
Application of water and release agent The task Increasing productivity, lowering material consumption To quickly activate the adhesive with wood fibreboards, steam is pressed into the briquette. The so-called steam shock makes high moisture of the entire fibre material unnecessary and optimises the quality of the boards. In addition, the fibre cake must not adhere to the mould substrate nor the press when it is loaded on the transport belt to prevent soiling the system. The task consist of applying water precision-metered on the fibre cake to reach these effects. Application of water The so-called steam shock activates the adhesive more quickly and reduces the pressing time. This results in higher production speeds and greater board density or smoother surface. In turn, this reduces sanding or grinding processes and lowers the material consumption. ....