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MediGene AG (via Public) / Identification of ten novel tumor-specific antigens immunogenic for T cells


Identification of ten novel tumor-specific antigens immunogenic for T cells
Planegg/Martinsried and Montréal - 10 April 2021. Medigene AG (Medigene, FSE: MDG1, Prime Standard), a clinical stage immuno-oncology company focusing on the development of T cell immunotherapies, today presents the screening and identification of novel immunogenic tumor-specific antigens (TSAs) derived from non-coding regions of the human genome at the American Association for Cancer Research Virtual Annual Meeting (AACR) 2021. The poster can be found on Medigene s website: https://www.medigene.com/technologies/abstracts
Significant efforts are being dedicated worldwide to identifying novel TSAs as targets for cancer immunotherapy. In this respect, not only known proteins but also non-coding genetic regions of cells are studied as sources of peptides that can be presented by HLA molecules at the surface of tumor cells and be recognized by T cell receptors (TCRs). Such TSAs can provide new targets ....

United States , Gary Waanders , Steven Klein , Dolores Schendel , Anna Niedl , Planegg Martinsried , Mary Ann Chang , Desbois Mackenzie , Centre Of Excellence , Cytovant Sciences Hk Ltd , Institute For Research , Communications Advisor , Business Development , Prime Standard , American Association , Cancer Research Virtual Annual Meeting , Chief Executive Officer , Chief Scientific Officer , Cytovant Sciences , ஒன்றுபட்டது மாநிலங்களில் , ஸ்டீவன் க்ளீன் , டோலோரஸ் திட்டமிடல் , மேரி ஆண்டு சாங் , மையம் ஆஃப் சிறப்பானது , நிறுவனம் க்கு ஆராய்ச்சி , வணிக வளர்ச்சி ,

Medigene AG: Focus on solid tumors - Discontinuation of MDG1021 development program


Medigene AG: Focus on solid tumors - Discontinuation of MDG1021 development program
Conference call today, 3.00 pm CET (9.00 am ET)
Planegg/Martinsried (pta025/28.01.2021/14:10) - 28 January 2021. The Executive Management of Medigene AG (Medigene, FSE: MDG1, Prime Standard), a clinical stage immuno-oncology company focusing on the development of T cell immunotherapies, with approval of the Supervisory Board decided today that, consistent with the company s recent decision to focus its development efforts on solid tumors, the MDG1021 development program is to be discontinued.
Recruitment for the Phase I clinical trial of the T cell receptor-modified T cell (TCR-T) therapy MDG1021 directed against the antigen HA-1 in patients suffering from relapsed or persistent blood cancers after allogeneic (non-self) hematopoietic stem cell transplantation, which was initiated at the Leiden University Medical Centre (LUMC) in the Netherlands in mid-2020, will be put on hold with imme ....

Gary Waanders , Dolores Schendel , Anna Niedl , Planegg Martinsried , Kai Pinkernell , Mary Ann Chang , Leiden University Medical Centre , Cytovant Sciences Hk Ltd , Executive Management , Prime Standard , Supervisory Board , Annual Report , Chief Medical Officer , Chief Development Officer , Chief Executive Officer , Chief Scientific Officer , Management Board , Cytovant Sciences , டோலோரஸ் திட்டமிடல் , மேரி ஆண்டு சாங் , நிர்வாகி மேலாண்மை , ப்ரைம் தரநிலை , மேற்பார்வை பலகை , ஆண்டு அறிக்கை , தலைமை மருத்துவ அதிகாரி , தலைமை வளர்ச்சி அதிகாரி ,