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Flagship startup Laronde wants to make protein-based drugs inside the body with 'endless RNA'


Laronde, a Flagship Pioneering startup, aims to make protein-based drugs in the body with ‘endless RNA’
Anissa Gardizy
© Courtesy of Laronde
An image of endless RNA, or eRNA, shows how the engineered molecule can latch onto a ribosome to make proteins.
In 2017, scientists at Flagship Pioneering were exploring different kinds of ribonucleic acid, or RNA, focusing on an unusual form of the molecule that had a circular shape, rather than a linear strand with two ends.
“When I saw that, I got excited,” said Avak Kahvejian, a general partner at the Cambridge venture capital firm. “I thought it was a way the cell was making really robust, stable RNAs, which are usually very unstable.” ....

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Bluebird executive joins Flagship startup Tessera as CMO


Dive Brief:
David Davidson, a longtime top executive at gene therapy developer Bluebird bio, will join the richly funded biotech startup Tessera Therapeutics as its chief medical and development officer, the latter company announced Wednesday. 
At Tessera, Davidson will be joined by former Spark Therapeutics and Moderna executive Hari Pujar, who will become chief operating officer, and by Lin Guey, most recently a vice president at Xilio Therapeutics who has been appointed head of rare disease strategy and operations. 
Launched by Flagship Pioneering last year, Tessera in January raised $230 million to advance its development of a new, more flexible type of genetic medicine, which the company and its venture backer have dubbed gene writing.   ....

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Tessera Rewrites the Genome Script Using Mobile Genetic Elements

Tessera Rewrites the Genome Script Using Mobile Genetic Elements
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