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Frontiers | Emergence of Dengue 4 as Dominant Serotype During 2017 Outbreak in South India and Associated Cytokine Expression Profile

Dengue virus infection is prevalent in tropical and sub-tropical regions of the world, which is fatal if untreated symptomatically. Emergence of new genotype within serotypes led to enhanced severity. The objective of the study is to identify the molecular characteristics of the DENV circulated during 2017 outbreak in Tamil Nadu, India and, to investigate the role of inflammatory cytokines in different ‘serotypes’ and in ‘dengue severity’. A total of 135 suspected samples were tested for DENV infection using IgM, IgG and qPCR assay; where 76 samples were positive for DENV and analysed for twelve inflammatory cytokines using ELISA. Serotyping shows 14 DENV-1, 22 DENV-2, 7 DENV-3 and 33 DENV-4, where DENV-4 was predominant. Among seventy-six, forty-two isolates were successfully sequenced for C-prM region and grouped. A lineage shift was observed in DENV-4 genotype. Irrespective of serotypes, IFNγ was significantly elevated than control and in primary infection indicating its ro ....

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Delhi stung by chikungunya, dengue, malaria; over 1,700 affected

Delhi stung by chikungunya, dengue, malaria; over 1,700 affected
Delhi stung by chikungunya, dengue, malaria; over 1,700 affected
Going By The Reports, The Number Of People Affected By Malaria Till August 26 Has Gone Up To 473 While The Number Of Those Affected With Chikungunya Stands At 339.
News Nation Bureau | Edited By : Tahir Qureshi
| Updated on: 29 Aug 2017, 10:01:27 PM
New Delhi:
Yet again, the capital city has been clinched by the vector-borne diseases, chikungunya, dengue, and malaria and a few days back a 12-year-old boy had succumbed to dengue shock syndrome at the Sir Ganga Ram Hospital.
Going by the reports, the number of people affected by malaria till August 26 has gone up to 473 while the number of those affected with chikungunya stands at 339. ....

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Understanding dengue better: Ten answers that explain more about the mosquito-borne disease

Blood in urine, stools, or vomit
Difficult or rapid breathing
Fatigue
What Lab tests are done to diagnose dengue?
Your doctor may order serial CBC (complete blood counts) and specific test for dengue antigen and antibodies and other tests as required.
What is the treatment of dengue?
No specific antiviral treatment exists for dengue. During the febrile phase, patients should stay well hydrated and take paracetamol. Avoid the use of aspirin and ibuprofen to minimize the potential for bleeding.
Additional supportive care in a hospital is required if the patient becomes dehydrated or develops warning signs of severe disease at or around the time of fever subsides. ....

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Zamboanga Sur dengue cases up 231% – The Manila Times

Zamboanga Sur dengue cases up 231% – The Manila Times
manilatimes.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from manilatimes.net Daily Mail and Mail on Sunday newspapers.

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How to keep your child safe from dengue

How to keep your child safe from dengue
freemalaysiatoday.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from freemalaysiatoday.com Daily Mail and Mail on Sunday newspapers.

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