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Leicester professor makes breakthrough that could help cancer victims live longer

First-Ever Survival Bump in Relapsed Mesothelioma


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Patients with progressive mesothelioma obtained a first-ever survival improvement with nivolumab (Opdivo) as second-line therapy, a randomized trial showed.
Median overall survival (OS) increased by almost 40%, and the progression-free interval also improved significantly with the immune checkpoint inhibitor as compared with placebo. In particular, a significant clinical benefit was evidence in patients with epithelioid subtype, the predominant mesothelioma histology.
PD-L1 expression status did not influence response to treatment, although only a third of patients tested positive for the biomarker, reported Dean Fennell, MD, of the University of Leicester in England, at the virtual World Conference on Lung Cancer. ....

New South Wales , Rina Hui , University Of Leicester , Crown Princess Mary Cancer Center , University Of Sydney , Dean Fennell , World Conference , Disorder Of Connective Tissue , Malignant Neoplastic Disease , Mass Of Pelvic Structure , Abdominal Mass , Neoplasm Of Pelvis , புதியது தெற்கு வேல்ஸ் , ரின ஹுய் , பல்கலைக்கழகம் ஆஃப் லெய்செஸ்டர் , கிரீடம் ப்ரிந்ஸெஸ் மேரி புற்றுநோய் மையம் , பல்கலைக்கழகம் ஆஃப் சிட்னி , டீன் ஃபெநல் , உலகம் மாநாடு , கோளாறு ஆஃப் இணைப்பு திசு , நிறை ஆஃப் இடுப்பு அமைப்பு , அடிவயிற்றைச் சார்ந்த நிறை ,

Nivolumab effective treatment for malignant mesothelioma


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(Singapore January 30, 2021 11:00 p.m. SPT/January 30, 2021 10:00 a.m. EST) Nivolumab monotherapy is an effective treatment option for relapsed malignant mesothelioma (MM), according to research presented today at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Malignant mesothelioma is an intractable cancer, and no phase III trial has yet shown an improvement in overall survival following the standard first line chemotherapy doublet comprising pemetrexed and cisplatin or carboplatin since it was licensed in 2004.
Professor Dean Fennell, chair of Thoracic Medical Oncology at the University of Leicester in collaboration with Professor Gareth Griffiths and his team at the Southampton Clinical Trials Unit, University of Southampton, UK, presented results of the Checkpoint Blockade for Inhibition of Relapsed Mesothelioma (CONFIRM) study, funded by Cancer Research UK/Stand Up To Cancer. The investigator-led, placebo-cont ....

United Kingdom , Gareth Griffiths , Giorgio Scagliotti , University Of Leicester , University Of Southampton , Eastern Cooperative Oncology Group , International Association , Lung Cancer World Conference , Dean Fennell , Thoracic Medical Oncology , Professor Gareth Griffiths , Southampton Clinical Trials Unit , Checkpoint Blockade , Relapsed Mesothelioma , Cancer Research United , Lung Cancer , Thoracic Oncology , ஒன்றுபட்டது கிஂக்டம் , கரேத் கிரிஃபித்ஸ் , பல்கலைக்கழகம் ஆஃப் லெய்செஸ்டர் , பல்கலைக்கழகம் ஆஃப் சவுத்தாம்ப்டன் , கிழக்கு கூட்டுறவு புற்றுநோயியல் குழு , சர்வதேச சங்கம் , நுரையீரல் புற்றுநோய் உலகம் மாநாடு , டீன் ஃபெநல் , தொராசி மருத்துவ புற்றுநோயியல் ,

IASLC hosts 2020 World Conference on Lung Cancer Singapore


The 2020 WCLC Presidential Symposium features:
National Lung Cancer Screening Program in Taiwan: The TALENT Study (Abstract 3309), Pan-Chyr Yang, M.D., from the National Taiwan University College of Medicine, Taipei/Taiwan.
International Tailored Chemotherapy Adjuvant Trial: ITACA (Abstract 1820) with Dr. Silvio Novello, University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy.
Surgical and Clinical Outcomes with Neoadjuvant Atezolizumab in Resectable Stage IB-IIIB NSCLC: LCMC3 Trial Primary Analysis (Abstract 3195) with Jay M. Lee, M.D., Ronald Reagan UCLA Medical Center in Los Angeles.
Registrational Phase 2 Trial of Sotorasib in Kras P. G12C Mutant NSCLC: First Disclosure of the CodeBreak100 Primary Analysis (Abstract 3037) with Bob Li, M.D., Memorial Sloan Kettering Cancer Center in New York City. ....

New York , United States , Memorial Sloan Kettering Cancer Center , New South Wales , United Kingdom , T Ai Pei , The University Of Sydney , Neoadjuvant Atezolizumab , Michael Boyer , Bob Li , Los Angeles , Pan Chyr Yang , Jaym Lee , Chris Obrien Lifehouse , Silvio Novello , University Of Leicester , International Tailored Chemotherapy Adjuvant Trial , National Lung Cancer Screening Program , National Taiwan University College Of Medicine , International Association , Lung Cancer Hosts , Lung Cancer Singapore January , Lung Cancer , Lung Cancer Screening Program , National Taiwan University College , San Luigi Gonzaga Hospital ,