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Leicester professor makes breakthrough that could help cancer victims live longer leicestermercury.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from leicestermercury.co.uk Daily Mail and Mail on Sunday newspapers.
email article Patients with progressive mesothelioma obtained a first-ever survival improvement with nivolumab (Opdivo) as second-line therapy, a randomized trial showed. Median overall survival (OS) increased by almost 40%, and the progression-free interval also improved significantly with the immune checkpoint inhibitor as compared with placebo. In particular, a significant clinical benefit was evidence in patients with epithelioid subtype, the predominant mesothelioma histology. PD-L1 expression status did not influence response to treatment, although only a third of patients tested positive for the biomarker, reported Dean Fennell, MD, of the University of Leicester in England, at the virtual World Conference on Lung Cancer. ....
E-Mail (Singapore January 30, 2021 11:00 p.m. SPT/January 30, 2021 10:00 a.m. EST) Nivolumab monotherapy is an effective treatment option for relapsed malignant mesothelioma (MM), according to research presented today at the International Association for the Study of Lung Cancer World Conference on Lung Cancer. Malignant mesothelioma is an intractable cancer, and no phase III trial has yet shown an improvement in overall survival following the standard first line chemotherapy doublet comprising pemetrexed and cisplatin or carboplatin since it was licensed in 2004. Professor Dean Fennell, chair of Thoracic Medical Oncology at the University of Leicester in collaboration with Professor Gareth Griffiths and his team at the Southampton Clinical Trials Unit, University of Southampton, UK, presented results of the Checkpoint Blockade for Inhibition of Relapsed Mesothelioma (CONFIRM) study, funded by Cancer Research UK/Stand Up To Cancer. The investigator-led, placebo-cont ....
The 2020 WCLC Presidential Symposium features: National Lung Cancer Screening Program in Taiwan: The TALENT Study (Abstract 3309), Pan-Chyr Yang, M.D., from the National Taiwan University College of Medicine, Taipei/Taiwan. International Tailored Chemotherapy Adjuvant Trial: ITACA (Abstract 1820) with Dr. Silvio Novello, University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy. Surgical and Clinical Outcomes with Neoadjuvant Atezolizumab in Resectable Stage IB-IIIB NSCLC: LCMC3 Trial Primary Analysis (Abstract 3195) with Jay M. Lee, M.D., Ronald Reagan UCLA Medical Center in Los Angeles. Registrational Phase 2 Trial of Sotorasib in Kras P. G12C Mutant NSCLC: First Disclosure of the CodeBreak100 Primary Analysis (Abstract 3037) with Bob Li, M.D., Memorial Sloan Kettering Cancer Center in New York City. ....