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Key mutations in Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points


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SARS-CoV-2 is a coronavirus, so named because spike proteins on its surface give it the appearance of a crown (‘corona’). The spike proteins bind to ACE2, a protein receptor found on the surface of cells in our body. Both the spike protein and ACE2 are then cleaved, allowing genetic material from the virus to enter the host cell. The virus manipulates the host cell’s machinery to allow the virus to replicate and spread.
As SARS-CoV-2 divides and replicates, errors in its genetic makeup cause it to mutate. Some mutations make the virus more transmissible or more infectious, some help it evade the immune response, potentially making vaccines less effective, while others have little effect. ....

Glasgow City , United Kingdom , Bo Meng , Ravi Gupta , Laboratory Of Molecular Biology , Pirbright Institute , Melinda Gates Foundation , Cambridge Biomedical Research Centre , University Of Cambridge , National Institute For Health Research , Glasgow Centre For Virus Research , Cambridge Institute Of Therapeutic Immunology , Research Council , Department Of Medicine , Cell Reports , Glasgow Centre , Virus Research , Molecular Biology , Cambridge Institute , Therapeutic Immunology , Infectious Disease , Professor Gupta , Dalan Bailey , Medical Research Council , National Institute , Health Research ,

Key mutations in Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points


University of Cambridge
One of the key mutations seen in the ‘Alpha variant’ of SARS-CoV-2 – the deletion of two amino acids, H69/V70 – enables the virus to overcome chinks in its armour as it evolves, say an international team of scientists.
SARS-CoV-2 is a coronavirus, so named because spike proteins on its surface give it the appearance of a crown (‘corona’). The spike proteins bind to ACE2, a protein receptor found on the surface of cells in our body. Both the spike protein and ACE2 are then cleaved, allowing genetic material from the virus to enter the host cell. The virus manipulates the host cell’s machinery to allow the virus to replicate and spread. ....

Glasgow City , United Kingdom , Bo Meng , Ravi Gupta , University Of Cambridge , Laboratory Of Molecular Biology , Glasgow Centre For Virus Research , Pirbright Institute , Cambridge Institute Of Therapeutic Immunology , Department Of Medicine , Cell Reports , Glasgow Centre , Virus Research , Molecular Biology , Cambridge Institute , Therapeutic Immunology , Infectious Disease , Professor Gupta , Dalan Bailey , கிளாஸ்கோ நகரம் , ஒன்றுபட்டது கிஂக்டம் , போ மெங் , ரவி குப்தா , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , ஆய்வகம் ஆஃப் மூலக்கூறு உயிரியல் , கிளாஸ்கோ மையம் க்கு வைரஸ் ஆராய்ச்சி ,