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Mass Extinction in The Human Gut Revealed by Fossil Remains of 2,000-Year-Old Feces


The microbes living in our gut are way less diverse than they were 2,000 years ago.
That s one of the key findings from a genomic analysis of fossilized human feces from rock shelters across North America and Mexico. Eight samples dating to between 1,000 and 2,000 years ago reveal microbes that are totally new to science, as well as others completely absent from the gut microbiome today.
 
By contrast, the modern gut microbiome contains vastly more antibiotic-resistant microbes than those of our ancestors. These findings could help us understand the connection - if there is one - between our diminished microbiome and the higher modern incidence of industrial chronic diseases such as diabetes and obesity. ....

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Research reveals ancient people had more diverse gut microorganisms


The University of Montana
Only an anthropologist would treasure millennia-old human feces found in dry caves.
Just ask Dr. Meradeth Snow, a University of Montana researcher and co-chair of UM’s Department of Anthropology. She is part of an international team, led by the Harvard Medical School-affiliated Joslin Diabetes Center, that used human “paleofeces” to discover that ancient people had far different microorganisms living in their guts than we do in modern times.
Snow said studying the gut microbes found in the ancient fecal material may offer clues to combat diseases like diabetes that afflict people living in today’s industrialized societies. ....

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Findings reveal insights about evolution of gut microbes in response to diet and environment


Harvard Medical School
Over the past several years, scientists have generated intriguing insights suggesting that variations in gut microbiomes-the collections of bacteria and other microbes in our digestive systems-may play harmful roles that precipitate the development of diabetes and other diseases.
By ERIC BENDER, Joslin Diabetes Cente
Now, researchers at Harvard Medical School and Joslin Diabetes Center have found dramatic differences between gut microbiomes from ancient North American peoples and modern microbiomes, offering further clues about how these microbes may have evolved with changing diets.
For the study, the scientists analyzed microbial DNA found in indigenous human paleofeces (desiccated excrement) from unusually dry caves in Utah and northern Mexico. ....

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Renalytix AI adds new biomarkers to platform for tricky to diagnose CKD


Photo by SCIEPRO/Getty Images
Clinical diagnostic company Renalytix AI has expanded its partnership with the Joslin Diabetes Center to integrate new biomarkers for kidney disease discovered by the center s researchers into the company’s KidneyIntelX platform.
KidneyIntelX is an in vitro diagnostic platform that assesses the risk of adverse kidney outcomes in patients with Type 2 diabetes and early-stage kidney disease. By examining a patient’s blood sample and medical history, the diagnostic generates a risk score for disease progression. Physicians can use the risk score to predict the progression of chronic kidney disease (CKD) and to guide treatments to help prevent kidney-function decline. ....

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