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Introduction It has been more than 1 year since the Covid-19 pandemic began in 2020 (1). The evolutionary origins of the SARS-CoV-2 virus can be partially traced to a lineage in bats; the closest known relative to SARS-CoV-2 (RaTG13) was found in a bat fecal sample taken from an abandoned mineshaft in Mojiang, China (2, 3). SARS-CoV-2 is proposed to have evolved via an intermediate host between bats and humans, or through natural selection in humans through direct contact with bats (2). Following a WHO-China investigation into the origins of the pandemic, a letter published in Science has pointed out analytical drawbacks of the report, that further investigatory efforts are needed to pinpoint the origin of SARS-CoV-2, and that both natural and laboratory spillover hypotheses must be taken seriously (4). Confirmation on the evolutionary origins of SARS-CoV-2 is critical for preventing future zoonotic outbreaks and pandemics.

Chen duSouth koreaCanping huangAllison wilsonJonathan lathamFront public healthFrontiers in public healthWuhan institute of virologyPublic healthWuhan institutePneumonia outbreakYunnan provinceMojiang miners passagingDisease preventionChinese phdMed abstract