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Comprehensive clinical sequencing opens door to the promise of precision medicine

Comprehensive clinical sequencing opens door to the promise of precision medicine
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Manjusha Pande , Annastasia Ouma , Michael Rusch , Chimene Kesserwan , Antonina Silkov , Emily Quinn , Zhaohui Gu , Roya Mostafavi , Michael Edmonson , Jian Wang , Michael Clay , Andrew Thrasher , Jeffery Klco , Brent Orr , Alberto Pappo , Lu Wang , Jinghui Zhang , Delaram Rahbarinia , Samuel Brady , Elise Gerhardt , Cheng Chang , Armita Bahrami , Raman Patel , David Wheeler , Rose Mcgee , Jamesr Downing ,

Study reveals mutations that drive therapy-related myeloid neoplasms in children

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IMAGE: Xiaotu Ma, Ph.D., St. Jude Computational Biology, and Jeffery Klco, M.D., Ph.D., St. Jude Pathology
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Credit: St. Jude Children s Research Hospital
Children treated for cancer with approaches such as chemotherapy can develop therapy-related myeloid neoplasms (a second type of cancer) with a dismal prognosis. Scientists at St. Jude Children s Research Hospital have characterized the genomic abnormalities of 84 such myeloid neoplasms, with potential implications for early interventions to stop the disease. A paper detailing the work was published today in
Nature Communications.
The somatic (cancer) and germline (inherited) genomic alterations that drive therapy-related myeloid neoplasms in children have not been comprehensively described, until now. The researchers used a variety of sequencing techniques (whole exome, whole genome and RNA) to characterize the genomic profile of 84 pediatric therapy-related myeloid neoplasm ....

United States , Jason Schwartz , Cristyn Branstetter , Scott Newman , Kim Nichols , Jing Ma , Ryan Hiltenbrand , Tamara Westover , Priyadarshini Kumar , Xiaolong Chen , Jennifer Kamens , John Easton , Jeffrey Rubnitz , Jeffery Klco , Xiaotu Ma , Tanja Gruber , Michael Walsh , Charles Mullighan , Jinghui Zhang , Samuel Brady , Lindsey Montefiori , J Robert Michael , Yanling Liu , Jamie Maciaszek , Huiyn Wu , Nature Communications ,