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Small changes made with gene editing cause severe deformities in plants LATEST VIDEOS Small changes made with gene editing cause severe deformities in plants Details New study points to unintended effects of gene editing in plants and potential negative effects on ecosystems Gene editing causes drastic unwanted effects in gene-edited plants including severe deformities, a new scientific publication in the journal Environmental Sciences Europe shows. This is the case even when the changes are intended by the gene editor to be small tweaks to existing genes rather than, for example, the introduction of new genetic material. More broadly, the study provides an overview of the negative effects on ecosystems that can result from the release of gene-edited plants. These unintended effects result from the intended changes induced by genome editing, which can affect various metabolic processes in the plants. ....
Study shows how collective behavior of bacterial colonies may contribute to antibiotic resistance The bacterial equivalent of a traffic jam causes multilayered biofilms to form in the presence of antibiotics, shows a study published today in eLife. The study reveals how the collective behavior of bacterial colonies may contribute to the emergence of antibiotic resistance. These insights could pave the way to new approaches for treating bacterial infections that help thwart the emergence of resistance. Bacteria can acquire resistance to antibiotics through genetic mutations. But they can also defend themselves via collective behaviors such as joining together in a biofilm - a thin, slimy film made up of many bacteria that is less susceptible to antibiotics. ....
Researchers identify a genetic defect that increases the risk of debilitating eye disease A genetic defect could hold the key to preventing or delaying the onset of a debilitating eye disease that can lead to vision loss and blindness. MacTel (macular telangiectasia type 2) affects one in 1,000 Australians. Symptoms include slow loss of vision, distorted vision and trouble reading. Because early signs of the disorder are subtle, it is difficult to diagnose. Researchers have identified an additional seven regions in the human genome that increase the risk of developing the condition, including a rare DNA mutation in the PHGDH gene, which will help clinicians to better diagnose and treat it. ....
Amino acids signaling controls whole-body glucose homeostasis, study shows Amino acids are a major nutrient type for humans and are used as building blocks and a source of energy for cells. Amino acids have also recently been recognized as chemical signals that control cell growth and metabolism. Researchers from Rutgers Cancer Institute of New Jersey previously identified a small protein called Rab1A that regulates amino acid signaling. In a recent study, researchers explored the physiological role of Rab1A in mammals using mice though a technique in which one of an organism s genes is made inoperative, known as genetic knockout. Steven Zheng, PhD, chief of Cancer Pharmacology and researcher at Rutgers Cancer Institute is senior author of the work and shares more about the findings published in the March 16 online edition of ....