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'Invisible' Stem Cells Evade Natural Killer Cells Using Immune 'Off-Switch'


Image by National Institutes of Allergy and Infectious Diseases
UC San Francisco scientists have discovered a new way to control the immune system’s “natural killer” (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection. The findings could also be used to enhance the ability of cancer immunotherapies to detect and destroy lurking tumors. 
The study, published Jan. 8, 2021, in the
Journal of Experimental Medicine, addresses a major challenge for the field of regenerative medicine, said lead author Tobias Deuse, MD, the Julien I.E. Hoffman, MD, Endowed Chair in Cardiac Surgery in the UCSF Department of Surgery.  ....

Nordrhein Westfalen , Tobias Deuse , Sonja Schrepfer , Ceren Saygi , Lewis Lanier , Sean Agbor Enoh , Vinhq Nguyen , Grigol Tediashvili , Julien Ie Hoffman , Alessia Gravina , Malik Alawi , J Michael Bishop , Sana Biotechnology Inc , National Institutes Of Allergy , Department Of Surgery , University Medical Center Hamburg , Stem Cell Immunobiology Laboratory , Division Of Adult Cardiothoracic Surgery , Department Of Microbiology , Johns Hopkins School Of Medicine , Parker Institute For Cancer Immunotherapy , Georgia State University , Blood Institute , National Heart , Us National Institutes Of Health , Helen Diller Family Comprehensive Cancer Center ,