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The elusive area postrema Nausea is a sense of malaise that all of us know. The sensation can be so overpowering that it leads us to wonder how and why this wretched condition happens. Researchers in Stephen Liberles’ lab at Harvard Medical School did more than wonder. They took the time and applied their expertise to study the neurons and circuits in the brain that control nausea, and reported their findings just in time for Thanksgiving. Deep in the brainstem, on the floor of the fourth ventricle lies the area postrema. A wide variety of evidence suggests that this region of the brain must be involved in nausea. Importantly, there is no blood brain barrier between the cells of the area postrema and the circulating plasma, so these cells are perfectly positioned to sample circulating poisons that most neurons would never encounter. However, the area postrema lies in a very specialized part of the brain which is very difficult to access experimentally. ....
(Credit: Reporter File Photo) Elaine Jackson Stack, a retired Justice of the New York State Supreme Court and a highly respected member of the Long Island legal community, passed away Dec.19 due to complications from COVID-19. Her death was confirmed by her daughter, Dede Stack Unger. Judge Stack, who was known universally as Jackie, was 89, and resided in Mineola and Shelter Island. She had been a long-time resident of East Hills, N.Y., where she raised her family and had served as deputy mayor. At her death, she was Of Counsel to the Garden City law firm of Barket Epstein Kearon Aldea & LoTurco, where she was head of the Family & Divorce Mediation Group. ....
E-Mail IMAGE: GLP1R neurons (red) play a critical role in detecting toxins in blood vessels (green) and initiating the nausea response. view more Credit: Chuchu Zhang , Stephen Liberles At some point, everyone experiences nausea. Whether it occurs after unwisely eating a week-old slice of pizza or as an accompaniment to a serious infection, that queasy, unsettling sensation centered around the stomach is a signal that something is amiss within the body and typically portends a bout of vomiting. Most of the time, nausea is only temporary. But for some people, such as those on certain chemotherapy regimens, it can be severe, chronic and even life-threatening when it prevents patients from adhering to treatment. ....