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Researchers see no change in disease activity in patients with IBD, COVID-19

Researchers see no change in disease activity in patients with IBD, COVID-19
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Dana Lukin , Randy Longman , Jill Roberts Center , Clinical Gastroenterology , ரேண்டி லாங்மேன் , ஜில் ராபர்ட்ஸ் மையம் , மருத்துவ இரைப்பை குடல் ,

Study finds 'Achilles heel' of Crohn's-linked bacteria

February 11, 2021
The discovery of an “Achilles’ heel” in a type of gut bacteria that causes intestinal inflammation in patients with Crohn’s disease may lead to more targeted therapies for the difficult-to-treat disease, according to researchers at Weill Cornell Medicine and NewYork-Presbyterian.
In a study published Feb. 5 in Cell Host and Microbe, the investigators showed that patients with Crohn’s disease have an overabundance of a type of gut bacteria called adherent-invasive Escherichia coli (AIEC), which
promotes inflammation in the intestine. Their experiments revealed that a metabolite produced by the bacteria interacts with immune system cells in the lining of the intestine, triggering inflammation. ....

Kenneth Simpson , Sloan Kettering , Weill Cornell , Monica Viladomiu , Gretchen Diehl , Ellen Scherl , Randy Longman , Maeva Metz , Jill Roberts Center , Division Of Gastroenterology , Jill Roberts Institute For Research , Cornell College Of Veterinary Medicine , Presbyterian Weill Cornell Medical Center , Weill Cornell Medicine , Cell Host , Inflammatory Bowel Disease , Weill Cornell Medical , Chun Jun Guo , Memorial Sloan Kettering , Cornell College , Veterinary Medicine , Jill Roberts Institute , Inflammatory Bowel , Weill Cornell Medicine Graduate School , Medical Sciences , கெநெத் சிம்ப்சன் ,

Potential New Therapeutic Target in Gut Bacteria Linked to Crohn's Disease

Researchers from Weill Cornell Medicine and New York-Presbyterian report they have discovered a weak spot in the gut bacteria, adherent-invasive Escherichia coli, which may lead to more targeted therapies for Crohn's disease. ....

New York , United States , Monica Viladomiu , Randy Longman , Jill Roberts Center , Jill Roberts Institute For Research , Presbyterian Weill Cornell Medical Center , Weill Cornell Medicine , New York Presbyterian , Cell Host , Jill Roberts Institute , Inflammatory Bowel Disease , Weill Cornell , Weill Cornell Medical , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ரேண்டி லாங்மேன் , ஜில் ராபர்ட்ஸ் மையம் , ஜில் ராபர்ட்ஸ் நிறுவனம் க்கு ஆராய்ச்சி , ப்ரெஸ்பிடீரியந் வெயில் கார்னெல் மருத்துவ மையம் , வெயில் கார்னெல் மருந்து , புதியது யார்க் ப்ரெஸ்பிடீரியந் , செல் தொகுப்பாளர் , ஜில் ராபர்ட்ஸ் நிறுவனம் , அழற்சி குடல் நோய் , வெயில் கார்னெல் ,

Discovery of 'Achilles heel' in gut bacteria may lead to targeted therapies for Crohn's disease

Discovery of ‘Achilles heel’ in gut bacteria may lead to targeted therapies for Crohn’s disease
The discovery of an Achilles heel in a type of gut bacteria that causes intestinal inflammation in patients with Crohn s disease may lead to more targeted therapies for the difficult to treat disease, according to Weill Cornell Medicine and NewYork-Presbyterian investigators.
In a study published Feb. 3 in
Cell Host and Microbe, the investigators showed that patients with Crohn s disease have an overabundance of a type of gut bacteria called adherent-invasive Escherichia coli (AIEC), which promotes inflammation in the intestine. Their experiments revealed that a metabolite produced by the bacteria interacts with immune system cells in the lining of the intestine, triggering inflammation. Interfering with this process, by either reducing the bacteria s food supply or eliminating a key enzyme in the process relieved gut inflammation in a mouse model of Crohn s disease ....

Weill Cornell , Monica Viladomiu , Ellen Scherl , Maeva Metz , Sloan Kettering , Randy Longman , Emily Henderson , Jill Roberts Center , Division Of Gastroenterology , Jill Roberts Institute For Research , Presbyterian Weill Cornell Medical Center , Weill Cornell Medicine , Cell Host , Inflammatory Bowel Disease , Weill Cornell Medical , Chun Jun Guo , Gretchen Diehl , Memorial Sloan Kettering , Kenneth Simpson , Jill Roberts Institute , Weill Cornell Medicine Graduate School , Medical Sciences , Inflammatory Bowel , Crohn 39s Disease , Immune System , Mouse Model ,