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Scientists create model of an early human embryo from skin cells


Credit: Monash University
AUSTRALIAN - LED INTERNATIONAL RESEARCH TEAM GENERATES THE FIRST MODEL OF EARLY HUMAN EMBRYOS FROM SKIN CELLS
In a discovery that will revolutionize research into the causes of early miscarriage, infertility and the study of early human development - an international team of scientists led by Monash University in Melbourne, Australia has generated a model of a human embryo from skin cells.
The team, led by Professor Jose Polo, has successfully reprogrammed these fibroblasts or skin cells into a 3-dimensional cellular structure that is morphologically and molecularly similar to human blastocysts. Called iBlastoids, these can be used to model the biology of early human embryos in the laboratory. ....

South Australia , United States , United Kingdom , Jennifer Zenker , Ross Coppel , Jose Polo , Xiaodong Ethan Liu , Bryan Lister , Amander Clark , Owen Rackham , Monash University Biomedicine Discovery Institute , Polo Lab , Monash University , Monash University Human Ethics , International Society For Stem Cell Research , University Of Western Australia , National University Of Singapore , Australian Regenerative Medicine Institute , Professor Jose Polo , Professor Polo , Biomedicine Discovery Institute , Jia Ping Tan , Professor Ryan Lister , Western Australia , Associate Professor Owen Rackham , Duke National University ,

Scientists create model of early human embryo from skin cells – study


Scientists have created a model of an early human embryo from skin cells, a discovery which they say will revolutionise research into the causes of early miscarriage, infertility and early human development.
Researchers have successfully reprogrammed these fibroblasts or skin cells into a 3D cellular structure that is similar to human blastocysts.
Called iBlastoids, these can be used to model the biology of early human embryos in the laboratory, according to a new study.
Scientists say this is a significant breakthrough for the future study of early human development and infertility.
A few days after an egg has been fertilised, it develops into a blastocyst. ....

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Scientists have created embryos. What does that mean? And what comes next?


Scientists have created embryos. What does that mean? And what comes next?
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Every cell in your body comes from a single cell: an egg, fertilised by a sperm. Each contains the exact same genetic blueprint for your life: your DNA.
Yet cells in your brain look and behave nothing like those in your muscle or skin.
Professor Jose Polo in front of images of his model embryos.
Credit:Monash University
Why? Because while each cell has the same instructions, each cell only reads certain sections – certain genes. A layer of what are called epigenetic instructions sit on top of your DNA, telling each cell which parts to read and which parts to ignore. ....

United Kingdom , New South Wales , Megan Munsie , Julian Koplin , Jose Polo , Ainsley Newson , Jason Smith , David Gardner , University Of Sydney School Public Health , University Of Melbourne , Murdoch Children Research Institute , Jia Ping Tan , Xiaodong Liy , Professor David Gardner , Reproductive Biology , Assisted Conception Laboratories , Murdoch Children , Professor Polo , ஒன்றுபட்டது கிஂக்டம் , புதியது தெற்கு வேல்ஸ் , ஜூலியன் கோப்ளின் , ஜோசே போளோ , ஐன்ஸலே நியூசன் , ஜேசன் ஸ்மித் , டேவிட் கார்ட்னர் , பல்கலைக்கழகம் ஆஃப் சிட்னி பள்ளி பொது ஆரோக்கியம் ,