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Flagging potential molecular predictors of response to biological therapies in ulcerative colitis Thousands of people around the world suffer from chronic bowel diseases. One such common disease is ulcerative colitis (UC), which causes inflammation and sores in the digestive tract of affected individuals. Interestingly, the symptoms of UC are caused by many of the body s natural defense biomolecules gone rogue! A few examples include abnormal elevation of tumor necrosis factor (TNF)-a and integrin levels. To treat UC, doctors prescribe several biologic therapies that act to bring down the elevated levels of these biomolecules. While this seems like a straightforward strategy to alleviate UC, sometimes these biologic therapies don t work on a specific subset of patients, aptly called non-responders. Much to the dismay of clinicians and non-responders, these situations lead to unnecessary medication, wasteful expenses, and delay in starting alternatives. Studies place such non-respon

United statesJi liEmily hendersonUnion medical collegeDepartment of gastroenterologyChinese academy of medical sciencesChinese medicalChinese academyMedical sciencesPeking union medical collegeஒன்றுபட்டது மாநிலங்களில்ஜி லிஎமிலி ஹென்டர்சன்தொழிற்சங்கம் மருத்துவ கல்லூரிதுறை ஆஃப் இரைப்பை குடல்சீன கலைக்கழகம் ஆஃப் மருத்துவ அறிவியல்