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Oral prodrug delivers carbon monoxide to protect against acute kidney injury An oral prodrug developed by a team of scientists led by Binghe Wang, Regents Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science. Although carbon monoxide (CO) gas is toxic in large doses, scientists have discovered it can have beneficial effects by reducing inflammation and protecting cells against injury. Previous studies have demonstrated the protective effects of CO against injury in the kidneys, lungs, gastrointestinal tract and liver, among other organs. For the past five years, Wang and his collaborators have worked to design a safe way to deliver CO to human patients via prodrugs inactive compounds that must undergo a chemical process in the body before releasing the active pharmacological agent.

United statesGeorgia state universityBinghe wangEmily hendersonUniversity of mississippiGeorgia state centerVanderbilt universityHarvard medical schoolFood drug administrationGeorgia research alliance eminent scholarRegent professorSweetn lowDrug administrationGeorgia research alliance eminentGeorgia stateஒன்றுபட்டது மாநிலங்களில்