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Nivolumab Alone Prevails in Resected Melanoma


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Dual checkpoint blockade with nivolumab (Opdivo) plus ipilimumab (Yervoy) failed to improve outcomes as adjuvant therapy for resected melanoma over nivolumab alone, the CheckMate 915 trial found.
In the intent-to-treat (ITT) population of more than 1,800 patients with stage IIIB-D/IV melanoma, relapse-free survival (RFS) at 2 years was nearly identical with the combination versus single-agent PD-1 blockade with nivolumab, at 64.6% and 63.2%, respectively (HR 0.92, 95% CI 0.77-1.09), reported Georgina Long, MBBS, PhD, of the University of Sydney.
In the subset with low PD-L1 expression ( ....

United States , New South Wales , Western Australia , Ian Ingram , Alexander Eggermont , Princess Maxima Center , American Association For Cancer Research , University Of Sydney , Georgina Long , American Association , Cancer Research , Pediatric Oncology , Medpage Today , Deputy Managing Editor , Malignant Adenomatous Neoplasm , Malignant Melanoma , Mass Of Body Structure , Neoplastic Disease , ஒன்றுபட்டது மாநிலங்களில் , புதியது தெற்கு வேல்ஸ் , மேற்கு ஆஸ்திரேலியா , ஈயந் இஂக்ரம் , ப்ரிந்ஸெஸ் அதிகபட்சம் மையம் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் சிட்னி , ஜார்ஜினா நீண்டது ,

Gene-based blood test for melanoma spread evaluates treatment progress


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A test that monitors blood levels of DNA fragments released by dying tumor cells may serve as an accurate early indicator of treatment success in people in late stages of one of the most aggressive forms of skin cancer, a new study finds.
Led by NYU Grossman School of Medicine and Perlmutter Cancer Center researchers, the investigation looked at adults with undetectable levels of freely circulating tumor DNA (ctDNA) four weeks into drug treatment for metastatic melanoma tumors that cannot be removed surgically (unresectable). The study showed that these patients, all of whom had common genetic changes (BRAFV600 mutations) linked to cancer, were living nearly twice as long without cancer growth as those who continued to have detectable levels. ....

United States , France General , New South Wales , Western Australia , Baden Wuberg , University Of Texas , David Polsky , Jennifer Wiggins , Dirk Schadendorf , Los Angeles , Antoni Ribas , Mahrukh Syeda , Matthew Squires , Eduard Gasal , Caroline Robert , Paul Nathan , James Garrett , Alfredw Kopf , Jan Brase , Keith Flaherty , Michael Davies , Broderickc Corless , Jean Jacques Grob , University Of California , Langone Health , Novartis Institute For Biomedical Research In Cambridge ,

Feeling 'so lucky' to be alive after receiving new melanoma treatment


Feeling ‘so lucky’ to be alive after receiving new melanoma treatment
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After losing a cousin to melanoma and being diagnosed with stage three of the same cancer, Sandra Moore feels lucky to be alive three years after receiving a potentially breakthrough treatment.
A new study published on Tuesday in the peer-reviewed medical journal
Nature Medicine has shown that a short course of immunotherapy drug treatment before surgery is effective in preventing the deadly spread of the disease in melanoma patients who are at high risk of the cancer recurring. ....

Burwood Girls High School , New South Wales , Western Australia , Dorothy Keefe , Alex Menzies , Melanoma Institute Australia , Georgina Long , Professor Dorothy Keefe , Institute Australia , Morning Edition , Sydney Morning Herald , Brisbane Time , புறவூட் பெண்கள் உயர் பள்ளி , புதியது தெற்கு வேல்ஸ் , மேற்கு ஆஸ்திரேலியா , டோரதி கீஃப் , அலெக்ஸ் மென்ஸீஸ் , மெலனோமா நிறுவனம் ஆஸ்திரேலியா , ஜார்ஜினா நீண்டது , ப்ரொஃபெஸர் டோரதி கீஃப் , நிறுவனம் ஆஸ்திரேலியா , காலை பதிப்பு , சிட்னி காலை ஹெரால்ட் , பிரிஸ்பேன் நேரம் ,