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Alzheimer protein APP regulates learning and social behavior in the healthy brain


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IMAGE: Lack of the APP family leads to abnormal positioning of neurons (yellow) in the hippocampus. Neurons lacking APP family proteins show fewer synaptic connections.
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Credit: Susanne Klein, Prof. Müller s research group, Heidelberg University
While the APP protein is well-known for its key role in Alzheimer s disease, its contribution to healthy brain function, by contrast, has remained largely unknown until now. Recently, an international research team, led by molecular biologist Prof. Dr Ulrike Müller from Heidelberg University, gained new insights on the physiological functions of the APP protein family by using a mouse model lacking APP. The absence of APP during brain development was shown to result in the malformation of important brain regions implicated in learning and memory. Consequently, these mice were severely impaired in their learning abilities and exhibited autistic-like behaviour. ....

Baden Wüberg , Technische Universit , University Of Mainz , German Research Foundation , University Of Zurich Switzerland , Molecular Biotechnology Of Heidelberg University , Institute Of Pharmacy , Heidelberg University , Functional Genomics , Molecular Biotechnology , Molecular Biology , Alzheimers Disease , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , பல்கலைக்கழகம் ஆஃப் ஸுரி சுவிட்சர்லாந்து , நிறுவனம் ஆஃப் மருந்தகம் , ஹைடெல்பெர்க் பல்கலைக்கழகம் , செயல்பாட்டு மரபியல் , மூலக்கூறு உயிரி தொழில்நுட்பவியல் ,

Geisinger awarded $3.6 million to study genetics of cancer | News, Sports, Jobs


May 7, 2021
DANVILLE The National Cancer Institute (NCI), part of the National Institutes of Health, has awarded a 5-year, $3.6 million contract to Geisinger to study the role of genetic variation in cancer.
Researchers from Geisinger and the NCI’s Division of Cancer Epidemiology and Genetics (DCEG) will analyze genetic data from Geisinger’s MyCode Community Health Initiative, a precision medicine project with more than 276,000 consented participants. The work will be led by David J. Carey, Ph.D., professor and chair of the Department of Molecular and Functional Genomics at Geisinger and a MyCode principal investigator, and Douglas Stewart, M.D., a senior investigator at DCEG. ....

United States , Davidj Carey , Douglas Stewart , Division Of Cancer Epidemiology , National Cancer Institute , Department Of Health , Human Services , National Institutes Of Health , Department Of Molecular , Geisinger Mycode Community Health Initiative , National Institutes , Cancer Epidemiology , Mycode Community Health Initiative , Functional Genomics , ஒன்றுபட்டது மாநிலங்களில் , டக்ளஸ் ஸ்டீவர்ட் , பிரிவு ஆஃப் புற்றுநோய் தொற்றுநோய் , தேசிய புற்றுநோய் நிறுவனம் , துறை ஆஃப் ஆரோக்கியம் , மனிதன் சேவைகள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , துறை ஆஃப் மூலக்கூறு , தேசிய நிறுவனங்கள் , புற்றுநோய் தொற்றுநோய் , செயல்பாட்டு மரபியல் ,

Geisinger awarded $3.6 million to study genetics of cancer


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DANVILLE, Pa., April 29, 2021 /PRNewswire/ The National Cancer Institute (NCI), part of the National Institutes of Health, has awarded a 5-year, $3.6 million contract to Geisinger to study the role of genetic variation in cancer.
Researchers from Geisinger and the NCI s Division of Cancer Epidemiology and Genetics (DCEG) will analyze genetic data from Geisinger s MyCode Community Health Initiative, a precision medicine project with more than 276,000 consented participants. The work will be led by David J. Carey, Ph.D., professor and chair of the Department of Molecular and Functional Genomics at Geisinger and a MyCode principal investigator, and Douglas Stewart, M.D., a senior investigator at DCEG. ....

United States , Davidj Carey , Douglas Stewart , Ashley Andyshak Hayes , Abigail Geisinger , Division Of Cancer Epidemiology , National Cancer Institute , Human Services , National Institutes Of Health , Geisinger Mycode Community Health Initiative , Geisinger Health System , Department Of Health , Department Of Molecular , Geisinger Commonwealth School Of Medicine , National Institutes , Cancer Epidemiology , Mycode Community Health Initiative , Functional Genomics , Geisinger Commonwealth School , Ashley Andyshak , ஒன்றுபட்டது மாநிலங்களில் , டக்ளஸ் ஸ்டீவர்ட் , பாங்கி கேய்சிங்கேர் , பிரிவு ஆஃப் புற்றுநோய் தொற்றுநோய் , தேசிய புற்றுநோய் நிறுவனம் , மனிதன் சேவைகள் ,