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Researchers uncover mechanism related to severe post-COVID-19 disease in children


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BOSTON A multidisciplinary team from MassGeneral Hospital for Children (MGHfC), Brigham and Women s Hospital and other institutions have identified the mechanism of how an extremely rare but serious post-COVID-19 complication develops in children and adolescents. Led by MGHfC pediatric pulmonologist Lael Yonker, MD, researchers determined that viral particles remaining in the gut long after an initial COVID-19 infection can travel into the bloodstream, instigating the condition called Multisystem Inflammatory Syndrome in Children (MIS-C).
The syndrome can occur several weeks after an initial infection; symptoms include high fever, abdominal pain, vomiting, diarrhea, rash and extreme fatigue. The hyperinflammatory response and cytokine storm seen in MIS-C can lead to extensive damage in the heart, liver and other organs. ....

United States , North Carolina , Amos Hostetter , Alessio Fasano , Los Angeles , David Walt , Lael Yonker , Moshe Arditi , National Institute Of Diabetes , Us Centers For Disease , Ragon Institute , European Biomedical Research Institute Of Salerno , Melinda Gates Foundation , University Of Maryland School Medicine , Blood Institute , National Heart , Wyss Institute For Biologically Inspired Engineering , Chieck Foundation , Mghfc Division Of Pediatric Gastroenterology , Sinai Medical Center , National Institutes Of Health , Immunological Diseases Research Center At Cedars , Drug Administration , Department Of Pediatrics , Massgeneral Hospital , Multisystem Inflammatory Syndrome ,