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COVID-19-Associated Seizures May be Common, Linked to Higher Risk of Death

Study examines the prevalence and risk factors for non-convulsive seizures among patients hospitalized with COVID-19 Boston – COVID-19 can have damaging effects on organs throughout the body, including the brain. A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) and Massachusetts General Hospital (MGH) demonstrated that some patients hospitalized with COVID-19 experience non-convulsive seizures, which may put them at higher risk of dying. The findings are published in the Annals of Neurology. “We found that seizures can happen in patients with severe COVID-19 infections, even those without any prior neurologic history, and that they are associated with worse outcomes,” says co-author Mouhsin Shafi, MD, PhD, an investigator in the Department of Neurology at BIDMC, Medical Director of the BIDMC electroencephalogram

Whole Genome Sequencing Reveals 13 New Gene Variants in Alzheimer's Disease

In a genome-wide association study (GWAS), the genomes of many individuals are scanned in search of common gene variants that occur more frequently in people who have a given disease, such as Alzheimer’s disease (AD). However, common Alzheimer’s-associated gene variants have accounted for less than half of the heritability of AD. A standard GWAS misses the rare gene variants (those occurring in less than 1% of the population). Now researchers at Massachusetts General Hospital (MGH), the Harvard T. H. Chan School of Public Health, and Beth Israel Deaconess Medical Center, report they have used whole genome sequencing (WGS) to discover rare genomic variants associated with AD, and have identified 13 variants.

First-of-its-kind study identifies 13 new Alzheimer's disease genes

First-of-its-kind study identifies 13 new Alzheimer’s disease genes In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer s disease (AD), researchers have identified 13 such variants (or mutations). In another novel finding, this study establishes new genetic links between AD and the function of synapses, which are the junctions that transmit information between neurons, and neuroplasticity, or the ability of neurons to reorganize the brain s neural network. These discoveries could help guide development of new therapies for this devastating neurological condition. Researchers at Massachusetts General Hospital (MGH), the Harvard T. H. Chan School of Public Health, and Beth Israel Deaconess Medical Center report these findings in

Thirteen new Alzheimer's genes identified in first-of-its-kind human genome study

13 new rare gene variants of Alzheimer's identified