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Cancer discovery could revive failed treatments for solid tumors


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IMAGE: Research from UVA s Jogender Tushir-Singh, PhD, explains why the antibody approaches effectively killed cancer tumors in lab tests but proved ineffective in people.
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Credit: Dan Addison | UVA Communications
New research from UVA Cancer Center could rescue once-promising immunotherapies for treating solid cancer tumors, such as ovarian, colon and triple-negative breast cancer, that ultimately failed in human clinical trials.
The research from Jogender Tushir-Singh, PhD, explains why the antibody approaches effectively killed cancer tumors in lab tests but proved ineffective in people. He found that the approaches had an unintended effect on the human immune system that potentially disabled the immune response they sought to enhance. ....

Sanchita Bhatnagar , Narmeens Rashid , Roxanna Mosavian , Paulad Bos , Jogender Tushir Singh , Divpriya Talwar , Karol Urbanek , Evan Lyerly , Edwardb Stelow , Rachisangt Tihagam , Tanmoy Mondal , J Chuck Harrell , Gururajn Shivange , Michael Battista , National Cancer Institute Institutes Of Health , School Of Medicine Department Biochemistry , Cancer Center , Department Of Defense Ovarian Cancer Research Program , Cancer Center Support Grant , National Cancer , National Institutes , Defense Breast Cancer Research Program , Defense Ovarian Cancer Research Program , சஞ்சிதா பட்நகர் , கரோல் அர்பானெக் , எவன் லயேறிலி ,

Researchers say they've made a discovery in a cancer treatment originally thought not to work


Researchers say they’ve made a discovery in a cancer treatment originally thought not to work
Cancer Center (FILE)
By Daniel Grimes | April 6, 2021 at 2:22 PM EDT - Updated April 6 at 2:22 PM
CHARLOTTESVILLE, Va. (WVIR) - Researchers at the University of Virginia Cancer Center say they’ve made a discovery that could revive a cancer treatment originally thought not to work.
It is an antibody treatment for solid cancer tumors like ovarian, colon, and triple negative breast cancers. Originally the treatment had an unintended effect, suppressing a person’s immune system in clinical trials.
Now researchers say they’ve figured out a way to make it work. ....

Sanchita Bhatnagar , Paulad Bos , Narmeens Rashid , Roxanna Mosavian , Jogender Tushir Singh , Divpriya Talwar , Karol Urbanek , Rachisangt Tihagam , Edwardb Stelow , Evan Lyerly , Tanmoy Mondal , J Chuck Harrell , Gururajn Shivange , Michael Battista , National Cancer Institute Institutes Of Health , University Of Virginia Cancer Center , Cancer Center , Department Of Defense Ovarian Cancer Research Program , School Medicine Department Of Biochemistry , Cancer Center Support Grant , Virginia Cancer Center , Discovery Could Revive Failed Treatments , Reveals Why Promising Antibody Approaches Proved , National Cancer , National Institutes , Defense Breast Cancer Research Program ,

Scientist at UVA School of Medicine developing gene therapy to help with Rett syndrome


Scientist at UVA School of Medicine developing gene therapy to help with Rett syndrome
A scientist at the UVA School of Medicine is developing a gene therapy for Rett syndrome.
By Daniel Grimes | March 15, 2021 at 6:22 PM EDT - Updated March 15 at 8:46 PM
CHARLOTTESVILLE, Va. (WVIR) - A scientist at the University of Virginia School of Medicine is developing a gene therapy that could help young girls across the country suffering from Rett syndrome.
Rett syndrome is caused by a mutation on the X chromosome. It affects brain development, which can lead to seizures and breathing problems.
Sanchita Bhatnagar is partnering with a scientist at the Center for Gene Therapy to bring about change for those living with Rett syndrome. They aim to manipulate cell regulators to only express healthy copies of certain proteins called microRNA’s. ....

Sanchita Bhatnagar , Kathrin Meyer , Abigail Wexner Research Institute , Alcyone Therapeutics Inc , University Of Virginia , A University Of Virginia School Medicine , Department Of Biochemistry , Licensing Ventures Group , University Of Virginia School Medicine , Virginia School , Gene Therapy , Ventures Group , Nationwide Children , Alcyone Therapeutics , Molecular Genetics , Rett Syndrome , Daniel Grimes , Yuva Scientist , Uva School Of Medicine , Rett Syndrome Uva Research , University Of Virginia Medicine , சஞ்சிதா பட்நகர் , கதிரின் மேயர் , பாங்கி வெக்ஸ்னர் ஆராய்ச்சி நிறுவனம் , பல்கலைக்கழகம் ஆஃப் வர்ஜீனியா , துறை ஆஃப் உயிர் வேதியியல் ,