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Why Costa Rica uses horseshoe crab blood in medicine

Costa Rica uses the blue blood of horseshoe crabs to test injectable drugs for contaminants.
Dr. Mario André Oreamuno Ávila, in charge of the Bioanalysis Unit of the Costa Rica’s Laboratory of Standards and Quality of Medicines (LNCM), explained his lab analyzes 400 batches of injectable drugs each year using this method.
Horseshoe crab blood reacts to the presence of bacteria and fungi by visibly coagulating. Analysis of this coagulation allows Oreamuno’s staff to verify the quality and the safety of drugs created or imported into Costa Rica.
As the U.S. National Oceanic and Atmospheric Administration explains:
Few people realize how important horseshoe crabs are to modern medicine. Because their blue, copper-based blood quickly clots in the presence of bacterial toxins, medical researchers use it to test intravenous drugs, vaccines, and medical devices, ensuring that they are free of bacterial contamination. Every year, many thousands of horseshoe crabs a ....

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Costa Rica detects South African, British coronavirus strains

Costa Rican researchers detected the South African variant of the coronavirus in a French tourist who was part of a group of 20 European visitors who tested positive for Covid-19 while traveling through the Central American country, authorities reported Tuesday.
The South African variant, considered more transmissible and resistant to some vaccines, was detected in a 65-year-old French man who presented symptoms of Covid-19 on January 31, the Costa Rican Ministry of Health said in a statement.
The Frenchman arrived in Costa Rica on January 16 with a group of his compatriots. Twenty tested positive for the coronavirus and six of them required hospitalization. ....

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Costa Rica reduces number of Covid beds due to drop in hospitalizations

Public hospitals in Costa Rica began to gradually reduce the beds designated to the care of Covid-19 patients following a sustained fall in infections over recent weeks.
The Costa Rican Social Security Fund (CCSS), which manages public hospitals, said Friday that it will gradually reactivate care for other ailments, which had been suspended preserve capacity for coronavirus patients.
“We hope to recover non-Covid face-to-face care services, which at the time should have been provided virtually, and other cases such as scheduled surgeries that had to be suspended,” said Mario Ruiz Cubillo, medical manager of the CCSS.
Daily cases of Covid-19 in Costa Rica went from more than 1,200 in December to around 400 since the second week of January. ....

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Costa Rica readies second study of equine serum to treat Covid

With the announcement from the Costa Rican Social Security Fund (CCSS) that the second study of the application of equine serum in Covid-19 patients is soon to begin, the scientists in charge prepare the modifications for these new tests, among which is adjusting the dose according to the patient’s weight.
According to Alberto Alape, researcher for the Clodomiro Picado Institute of the University of Costa Rica (UCR), the study involves four groups of patients who will receive different doses.
“In the first trial, a single dose was given. Some patients responded well, and in others, the medication had no effect,” Alape explained. “One interpretation of the results is that the patients were of very different characteristics; there were some of more than 150 kg and others of 60 kg, so the same dose for the patients was diluted in the patient’s mass and did not have the same result. In conclusion, for the second study, the dose will be adjusted according to the pati ....

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