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NEW YORK, NY (Jan. 11, 2021) Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer s origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer s transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.
The study, published Jan. 11 in
Cell, confirms that Master Regulators provide the molecular logic that integrates the effect of many different and patient-specific mutations to implement the transcriptional state of a specific tumor subtype, thus greatly expanding the fraction of patients who may respond to the same treatment. ....

New York , United States , Mailman School Of Public Health , Columbia University , Lhospitalet De Llobregat , Comunidad Autonoma De Cataluna , Asuntos Economicosy Transformacion , Prems Subramaniam , Marianoj Alvarez Darwinhealth , Mariano Alverez , Eugenef Douglass , Andrea Califano , Salud Carlos , Marianoj Alvarez , Columbia University Irving Medical Center , Vagelos College Of Physicians , Columbia Precision Oncology Initiative , National Cancer Institute , Catalan Institute Of Oncology , Us National Institutes Of Health , Federicom Giorgi University Of Bologna , School Of Arts , Bellvitge Institute For Biomedical Research , College Of Dental Medicine , Herbert Irving Comprehensive Cancer Center , Evano Paull Columbia University ,