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Optimising spray-dried solid dispersions to improve solubility SHARES Manufacturing drug products with low solubility APIs (BCS type II and IV) has its challenges, in this article, Javier Gurrea, a Spray Drying Manufacturing Scientist at Idifarma, explains why spray drying offers a great way to overcome them. Today’s active pharmaceutical ingredients (API) are increasingly insoluble and that can pose serious problems for formulators looking to manage bioavailability and dosing of their formulations. Moreover, the trend is building: around 40 percent of new potentially active chemical compounds are poorly soluble in water or lipophilic solutions. 1 These drugs are classified in the Biopharmaceutical Classification System (BCS) as Class II (low solubility and high permeability) or Class IV (low solubility and low permeability). ....