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Scientists seek to block pathogen's most reliable weapon to cause severe malaria


Scientists seek to block pathogen’s most reliable weapon to cause severe malaria
The parasites that cause severe malaria are well-known for the sinister ways they infect humans, but new research may lead to drugs that could block one of their most reliable weapons: interference with the immune response.
In the study, scientists defined the atomic-level architecture of the connection between a protein on the surface of a parasite-infected red blood cell when it binds to a receptor on the surface of an immune cell.
When that protein-receptor connection is made under normal circumstances, the infected red blood cell, hijacked by the disease-causing parasite, de-activates the immune cell - meaning the body won t fight the infection. A drug designed to fit into that space could block the interaction, allowing the immune system to get to work clearing away the pathogen. ....

Kai Xu , Emily Henderson , Ohio State University , National Institutes Of Health , National Institutes , Assistant Professor , Veterinary Biosciences , கை ஐயூ , எமிலி ஹென்டர்சன் , ஓஹியோ நிலை பல்கலைக்கழகம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தேசிய நிறுவனங்கள் , உதவியாளர் ப்ரொஃபெஸர் , கால்நடை உயிர் அறிவியல் ,