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Frontiers | Emergence of Dengue 4 as Dominant Serotype During 2017 Outbreak in South India and Associated Cytokine Expression Profile

Dengue virus infection is prevalent in tropical and sub-tropical regions of the world, which is fatal if untreated symptomatically. Emergence of new genotype within serotypes led to enhanced severity. The objective of the study is to identify the molecular characteristics of the DENV circulated during 2017 outbreak in Tamil Nadu, India and, to investigate the role of inflammatory cytokines in different ‘serotypes’ and in ‘dengue severity’. A total of 135 suspected samples were tested for DENV infection using IgM, IgG and qPCR assay; where 76 samples were positive for DENV and analysed for twelve inflammatory cytokines using ELISA. Serotyping shows 14 DENV-1, 22 DENV-2, 7 DENV-3 and 33 DENV-4, where DENV-4 was predominant. Among seventy-six, forty-two isolates were successfully sequenced for C-prM region and grouped. A lineage shift was observed in DENV-4 genotype. Irrespective of serotypes, IFNγ was significantly elevated than control and in primary infection indicating its ro ....

United States , United Kingdom , New Delhi , Tamil Nadu , Sri Lanka , Republic Of , North Western , City Of , Andaman And Nicobar Islands , Saudi Arabia , Gonzalez Mateos , Flores Aguilar , Flavivirus Serocomplex Cross , Vellore Cecilia , Cladec Cecilia , Lakshmana Rao , Alwin Prem Anand , Andrea Wizenmann , Cruz Hernandez , Oswaldo Cruz , Gowri Sankar , Triuppur Alagarasu , Pondicherry Hoti , Waal Malefyt , Lopez Martinez , Nadu Manakkadan ,

Visiting a hospital? Health systems tighten rules amid COVID-19 case jump


Visiting a hospital? Health systems tighten rules amid COVID-19 case jump
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Updated: 5:27 PM CDT Jul 23, 2021
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Updated: 5:27 PM CDT Jul 23, 2021
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LET’S TALK NUMBERS. OFFICIALS SAY THE DELTA VARIANT IS TO BLAME FOR THE RECENT JUMP IN CASES. TAKE A LOOK AT THIS, MORE THAN 3100 NEW CASES IN LOUISIANA AND IT, 11 AND NEW DEATHS. AS FOR THE NUMBER OF HOSPITALIZATIONS, THOSE JUMPED AGAIN. WE ARE ORVE 1000 WITH 1008 PEOPLE HOSPITALIZED STATEWIDE, 82 OF THOSE PEOPLE ARE ON VENTILATORS. AS MORE PEOPLE ARE ADMITTED INTO HOSPITALS BATTLING COVID, THERE WILL BE CHANGES. MEDICAL CENTERS ACROSS OUR AREA ARE TIGHTENING UP THEIR RULES BECAUSE OF THIS TRD.EN HARRISON GOLDEN JOINS US LIVE AT ONE HOSPITAL ON THE NORTH SHORE. WHAT SHOULD HOSPITAL VISITORS KNOW BEFORE THEY GO? HARRISON: WE ARE HERE AT LAKEVIEW REGIONAL MEDICAL CENTER IN COVINGTON. THEY HAVE BEEN SEEING THE UPTICK AS WELL AS MUCH OF THE ST ....

United States , New Orleans , Lakeview Regional Medical Center , Ochsner Healthall , Inpatient Behavioral Health , Tulane Health System , Emergency Department , Ochsner Health , Family Birthing Center , Tammany Health System , Tulane Health , Tulane Health Lakeview Regionalto , Tammany Health System Hospital , North Oaks , Visiting Hours , Emergency Departments , Urgent Care Locations , Emergency Room , Urgent Care , Infusion Suites , Outpatient Clinics , Adult Patients , Pediatric Patients , Special Circumstances , Comfort Care , Adult Inpatient ,