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Fast heart, slow heart: Changes in the molecular motor myosin explain the difference


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The human heart contracts about 70 times per minute, while that of a rat contracts over 300 times; what accounts for this difference? In a new study publishing 10th June in the open-access journal
PLOS Biology, led by Michael Geeves and Mark Wass of the University of Kent and Leslie Leinwand from the University of Colorado Boulder, reveal the molecular differences in the heart muscle protein beta myosin that underly the large difference in contraction velocity between the two species.
Myosin is a molecular motor - an intricate nanomachine that forms the dynamic core of a muscle s contractile machinery, burning cellular chemical energy in the form of ATP to rapidly and reversibly exert force against cables of actin. In so doing, it pulls the ends of the muscle cell closer together, causing muscle contraction. It has long been known that the maximal rate of contraction, called V0, varies predictably among mammals: In small mammals with their high metabolic ra ....

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Shortage Concerns Drive Rising Prices for Ag Plastic


Farmers are facing fast rising prices for agricultural plastics as manufacturers try to recover from February’s severe freeze in Texas.
Several distributors of bale wrap, silage covers and other plastics used by farmers have reported delays in ordering products, increased demand and rising prices.
Some of the snarl appears to be self-inflicted, with fears of a shortage prompting people to buy more and earlier than normal. But the root cause lies with Mother Nature.
Many chemical plants around Houston shut down in mid-February when the area was slammed by single-digit temperatures, ice and snow that resulted in massive power outages. The area produces most of the nation’s resin used in plastic manufacturing. ....

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New study suggests better approach in search for COVID-19 drugs


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Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of COVID-19, revealing vital clues for the discovery of antiviral drugs.
Researchers compared SARS-CoV-2 and the closely related virus SARS-CoV, the cause of the 2002/03 SARS outbreak. Despite being 80% biologically identical, the viruses differ in crucial properties. SARS-CoV-2 is more contagious and less deadly, with a fatality rate of 2% compared to SARS-CoV s 10%. Moreover, SARS-CoV-2 can be spread by asymptomatic individuals, whereas SARS-CoV was only transmitted by those who were already ill.
Most functions in cells are carried out by proteins; large molecules made up of amino acids. The amino acid sequence determines the function of a protein. Viruses encode proteins that reprogramme infected cells to produce more viruses. Despite the proteins of SARS-C ....

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