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A call to arms


Science s COVID-19 reporting is supported by the Heising-Simons Foundation
ILLUSTRATION: STEPHAN SCHMITZ/FOLIO ART
In March 2020, as the scope of the COVID-19 pandemic was coming into view, Jen Nwankwo and colleagues turned a pair of artificial intelligence (AI) tools against SARS-CoV-2. One newly developed AI program, called SUEDE, digitally screens all known druglike compounds for likely activity against biomolecules thought to be involved in disease. The other, BAGEL, predicts how to build inhibitors to known targets. The two programs searched for compounds able to block human enzymes that play essential roles in enabling the virus to infect our cells.
While SUEDE sifted through 14 billion compounds in just hours and spit out a hit, BAGEL made equally fast work of designing a lead. Nwankwo, CEO of a Massachusetts biotech startup called 1910 Genetics, asked a chemical company partner to synthesize the compounds. A week or so later, her team received the orders, added ....

University Of Massachusetts Medical School , United States , United Kingdom , Francis Collins , David Baker , Matthew Disney , Celia Schiffer , Ridgeback Biotherapeutics , Jen Nwankwo , Sandra Weller , Emmeline Blanchard , Mark Denison , Annaliesa Anderson , Evrys Bio , Daniel Vitt , Marla Weetall , Charlotte Lanteri , Andrew Mesecar , Richard Plemper , Lillian Chiang , Heising Simons Foundation , Walter Reed Army Institute Of Research , Purdue University , Scripps Research Institute , Gilead Sciences , National Institutes Of Health ,

Researchers race to develop antiviral weapons to fight the pandemic coronavirus


Science’s COVID-19 reporting is supported by the Heising-Simons Foundation.
In March 2020, as the scope of the COVID-19 pandemic was coming into view, Jen Nwankwo and colleagues turned a pair of artificial intelligence (AI) tools against SARS-CoV-2. One newly developed AI program, called SUEDE, digitally screens all known druglike compounds for likely activity against biomolecules thought to be involved in disease. The other, BAGEL, predicts how to build inhibitors to known targets. The two programs searched for compounds able to block human enzymes that play essential roles in enabling the virus to infect our cells.
While SUEDE sifted through 14 billion compounds in just hours and spit out a hit, BAGEL made equally fast work of designing a lead. Nwankwo, CEO of a Massachusetts biotech startup called 1910 Genetics, asked a chemical company partner to synthesize the compounds. A week or so later, her team received the orders, added each compound in turn to human cells, an ....

University Of Massachusetts Medical School , United States , United Kingdom , Francis Collins , David Baker , Matthew Disney , Celia Schiffer , Ridgeback Biotherapeutics , Jen Nwankwo , Sandra Weller , Emmeline Blanchard , Mark Denison , Annaliesa Anderson , Evrys Bio , Daniel Vitt , Marla Weetall , Charlotte Lanteri , Andrew Mesecar , Richard Plemper , Lillian Chiang , Walter Reed Army Institute Of Research , Purdue University , Nature Communications , Uconn Health , University Of Washington , Vanderbilt University ,

From 'Jolene' To Vaccine: Dolly Parton Gets COVID-19 Shot She Helped Fund


Dolly Parton, pictured performing in May 2014, shared a video of herself getting her first dose of the Moderna COVID-19 vaccine on Tuesday. (Wade Payne/Invision/via AP)
Country music legend Dolly Parton got a taste of her own medicine on Tuesday when she received a dose of the COVID-19 vaccine whose research she helped fund.
Parton, 75, documented the moment in a video posted to social media in which she encouraged eligible viewers to get the shot and broke into a modified rendition of Jolene to that effect.
Vaccine, vaccine, vaccine, vaccine, I m begging of you please don t hesitate, she sang. Vaccine, vaccine, vaccine, vaccine, cause once you re dead then that s a bit too late. ....

Naji Abumrad , Mark Denison , Dolly Parton America , Jad Abumrad , Dolly Parton , Vanderbilt University Medical Center , Division Of Pediatric Infectious , Vanderbilt University , Associated Press , Pediatric Infectious , New England Journal , குறி மறுப்பு , டோலி பார்‌டந் அமெரிக்கா , டோலி பார்‌டந் , வாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம் , பிரிவு ஆஃப் குழந்தை தொற்று , வாண்டர்பில்ட் பல்கலைக்கழகம் , தொடர்புடையது ப்ரெஸ் , குழந்தை தொற்று , புதியது இங்கிலாந்து இதழ் ,