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CD40 drug before surgery can benefit patients with early-stage pancreatic cancer

Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. ....

United States , Roberth Vonderheide , Katelynt Byrne , Emily Henderson , Science University , Johns Hopkins University , Oregon Health , Perelman School Of Medicine , Abramson Cancer Center , American Association For Cancer Research , University Of Washington , University Of Pennsylvania , Case Western Reserve University , Fred Hutchinson Cancer Research Center , Dana Farber Cancer Institute , Perelman School , American Association , Cancer Research , Johns Hopkins , Dana Farber Cancer , Study Senior Author , Pancreatic Cancer , Immune Response , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , அறிவியல் பல்கலைக்கழகம் ,

Study reveals new insights into the effects of chemotherapy on tumor microenvironment

Research from Queen Mary University of London has revealed novel insights into the effects of chemotherapy on the tumor microenvironment (TME). ....

United States , United Kingdom , Fran Balkwill , Emily Henderson , Cancer Immunology Research , American Association For Cancer Research , Queen Mary University Of London , Cancer Research United Kingdom , Queen Mary University , American Association , Cancer Research , Professor Fran Balkwill , Wellcome Trust , Blood Vessels , Immune Response , Ovarian Cancer , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , எமிலி ஹென்டர்சன் , புற்றுநோய் நோயெதிர்ப்பு ஆராய்ச்சி , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , ராணி மேரி பல்கலைக்கழகம் ஆஃப் லண்டன் , புற்றுநோய் ஆராய்ச்சி ஒன்றுபட்டது கிஂக்டம் , ராணி மேரி பல்கலைக்கழகம் , அமெரிக்கன் சங்கம் , புற்றுநோய் ஆராய்ச்சி ,

BeiGene Presents Clinical Data on Sitravatinib in Combination with Tislelizumab at the AACR Annual Meeting 2021

Press release content from Business Wire. The AP news staff was not involved in its creation.
BeiGene Presents Clinical Data on Sitravatinib in Combination with Tislelizumab at the AACR Annual Meeting 2021
April 11, 2021 GMT
CAMBRIDGE, Mass. & BEIJING (BUSINESS WIRE) Apr 11, 2021
BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160), a commercial-stage biotechnology company focused on developing and commercializing innovative medicines worldwide, today announced that clinical data on its anti-PD-1 antibody tislelizumab, in combination with the investigational spectrum-selective kinase inhibitor sitravatinib being jointly developed with Mirati Therapeutics, Inc. (Mirati), were presented in two oral presentations at the American Association for Cancer Research (AACR) Annual Meeting 2021. Data presented at the meeting were from two cohorts of a Phase 1b trial (NCT03666143), in patients with unresectable or metastatic melanoma who were refractory or resistant to PD-1/L1 inhibitor ....

United States , New Zealand , United Kingdom , Chuanliang Cui , Bristol Myers Squibb , Jeffrey Goh , Yong Ben , Beigene Ltd , Oncologist At Icon Cancer Centre , Mirati Therapeutics Inc , Exchange Commission , Tislelizumab Clinical Program , China National Medical Products Administration , American Association For Cancer Research , Amgen Inc , Mirati Therapeutics , American Association , Cancer Research , Annual Meeting , Chief Medical Officer , Metastatic Melanoma Refractory , Beijing Cancer Hospital , Medical Oncologist , Icon Cancer Centre , Biologics License Applications , Drug Evaluation ,

High expression of cell death genes may increase risk of early death from lung cancer

High expression of cell death genes may increase risk of early death from lung cancer
Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer are at increased risk of dying early from their disease, researchers report.
Also seemingly paradoxically, patients with high expression of this 21-gene cell death signature the researchers have identified, have indicators that their immune system is attacking the cancer, like higher levels of cytotoxic T cells, which typically kill cancer.
But they also have high levels of molecules that can suppress those T cells, helping transform them into dysfunctional, exhausted T cells, they report in the journal ....

United States , Ravindra Kolhe , Emily Henderson , Centers For Disease , National Cancer Institute , National Human Genome Research Institute , Drug Administration , Cancer Research Institute , College Of Georgia Department Pathology , Georgia Esoteric , Medical College , Georgia Department , Cancer Genome Atlas , National Human Genome Research , Disease Control , Cancer Research , Cell Death , Lung Cancer , Immune System , Pd L1 , ஒன்றுபட்டது மாநிலங்களில் , ரவின்ற கொள்ே , எமிலி ஹென்டர்சன் , மையங்கள் க்கு நோய் , தேசிய புற்றுநோய் நிறுவனம் , தேசிய மனிதன் மரபணு ஆராய்ச்சி நிறுவனம் ,

UAE: 'Hot chemotherapy' gives new hope to cancer patients - News

UAE: ‘Hot chemotherapy’ gives new hope to cancer patients
Nandini Sircar/Dubai
Reuters
Though advanced, morbidity, mortality and complications remained high in this procedure.
Just when his cancer was getting worse, Sudanese doctor Mohammad Abdel Rahman took a risk and agreed to an emerging procedure called ‘hot chemotherapy’. Thanks to the complex operation, he is now feeling much better with up to ‘99 per cent of his tumour’ gone.
“I am glad the UAE has surgeons who are trained to do these complex procedures and where one can expect to have the level of care to support such complexity. This country is truly passionate about innovation in healthcare,” said 36-year-old Mohammad, a Ras Al Khaimah resident battling middle rectal cancer. ....

Ash Shariqah , United Arab Emirates , Ras Al Khaimah , Ras Al Khaymah , Al Zahra , Abu Dhabi , Mohammad Abdelrahman , Sadir Alrawi , Arun Karanwal , Burjeel Specialty Hospital Sharjah , Burjeel Medical City , Mehdi Afrit , Burjeel Specialty Hospital , Canadian Specialist Hospital , Prime Hospital , Hot Chemotherapy , Cancer Patients , ஒன்றுபட்டது அரபு அமீரகங்கள் , ராஸ் அல் கைமா , அல் ஸஹ்ரா , அருண் கரன்வால் , பர்ஜீல் சிறப்பு மருத்துவமனை ஷார்ஜா , பர்ஜீல் மருத்துவ நகரம் , பர்ஜீல் சிறப்பு மருத்துவமனை , கனடியன் நிபுணர் மருத்துவமனை , ப்ரைம் மருத்துவமனை ,