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New drug target for Ebola, Marburg viruses


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IMAGE: UIC s Lijun Rong is part of a team of UIC researchers who have identified a previously unknown site on filoviruses a type of virus, like Ebola, that causes hemorrhagic.
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Credit: Jenny Fontaine/UIC
Ebola and Marburg are among the most deadly viruses, with mortality rates from these infections ranging from 25% to 90%. While no drugs currently are available on the market to prevent infection from these viruses they belong to a category of viruses called filoviruses, which are known to cause hemorrhagic fever researchers have identified a few small drug molecules that can block filoviruses from infecting cells by occupying a single site on a glycoprotein in the virus. ....

United States , Benjamin Ramirez , Lijun Rong , Hyun Lee , Erica Ollmann Saphire , Raghad Nowar , Michael Caffrey , Laura Cooper , Rui Xiong , Yangfeng Li , Chan Cheng , Adam Schafer , Gregory Thatcher , Norton Peet , Lajolla Institute Of Immunology , University Of Illinois Chicago , National Institutes Of Health , Chicago Biosolutions Inc , College Of Medicine , College Of Pharmacy , University Of Arizona , Illinois Chicago , Chicago Biosolutions , Lajolla Institute , National Institutes , Medicine Health ,