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Written by Erika Watts on May 4, 2021 Fact checked by Ferdinand Lali, Ph.D. A recent study tests combinations of drugs for the treatment of COVID-19. Himanshu Vyas/Hindustan Times via Getty Images Although vaccines are now available for most of the world, a more successful treatment for COVID-19 is still necessary. Researchers believe that a combination of Food and Drug Administration (FDA)-approved antiviral medications could help people with SARS-CoV-2 infections. They combined the drug remdesivir, which is effective against Ebola, with drugs that can treat hepatitis C. With worldwide COVID-19 cases on the rise again, the race to find an effective treatment for the disease continues. ....
Share Remdesivir is currently the only antiviral drug approved in the U.S. for treating COVID-19 patients. In a paper published this week in Cell Reports, researchers from The University of Texas at Austin, Rensselaer Polytechnic Institute (RPI) and the Icahn School of Medicine at Mount Sinai showed that four drugs used to treat hepatitis C render remdesivir 10 times better at inhibiting the coronavirus in cell cultures. These results indicate that a mixture containing remdesivir and a repurposed hepatitis C virus (HCV) drug could potentially function as a combination antiviral therapy for SARS-CoV-2. Such an antiviral could provide an immediate treatment for unvaccinated people who become infected and for vaccinated people whose immunity has waned. ....
Medications for Hepatitis C Enhance Remdesivir s Activity by Angela Mohan on April 28, 2021 at 6:34 PM Cell Reports. Mixture containing remdesivir and a repurposed hepatitis C virus (HCV) drug could potentially function as a combination antiviral therapy for SARS-CoV-2. Such an antiviral could provide an immediate treatment for unvaccinated people who become infected and for vaccinated people whose immunity has waned. But Remdesivir must be administered intravenously, limiting its use to patients already admitted to the hospital. Our goal is to develop a combination of oral drugs that can be administered to outpatients before they are sick enough to require hospitalization, said Robert M. Krug, professor emeritus of molecular biosciences at UT Austin and co-author of the paper. ....
IMAGE: Synergy Scores Mount Sinai Health System A combination of remdesivir, a drug currently approved in the United States for treating COVID-19 patients, and repurposed drugs for hepatitis C virus (HCV) was 10 times more effective at inhibiting SARS-CoV-2, the virus that causes COVID-19. The combination therapy points a way toward a treatment for unvaccinated people who become infected, as well as for vaccinated people whose immunity has waned, for example due to the emergence of virus variants that escape this immune protection. Four HCV drugs simeprevir, vaniprevir, paritaprevir, and grazoprevir in combination with remdesivir boosted the efficacy of remdesivir by as much as 10-fold, the researchers reported today in ....
Hepatitis C Drugs Boost Remdesivir’s Antiviral Activity Against COVID-19 Drugs used to treat hepatitis C render remdesivir 10 times better at inhibiting the coronavirus in cell cultures, according to new study. Illustration credit: Jenna Luecke/University of Texas at Austin. AUSTIN, Texas Remdesivir is currently the only antiviral drug approved in the U.S. for treating COVID-19 patients. In a paper published this week in Cell Reports, researchers from The University of Texas at Austin, Rensselaer Polytechnic Institute (RPI) and the Icahn School of Medicine at Mount Sinai showed that four drugs used to treat hepatitis C render remdesivir 10 times better at inhibiting the coronavirus in cell cultures. ....