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This article was originally published on Reality Sandwich, and appears here with permission. Ketamine is a versatile compound that acts as an anesthetic, analgesic, and potent, fast-acting antidepressant in medical settings. When used recreationally, it produces powerful psychedelic and dissociative effects. Similar to the manufacturing of LSD, the synthesis of ketamine is not an easy task and the starting materials are difficult to obtain. For these reasons, clandestine labs do not commonly synthesize illicit ketamine. Instead, a proportion of commercially-made ketamine is diverted into the illicit market and smuggled over borders. India and China are two major hubs for the manufacturing of ketamine. Both of these countries produce its hydrochloride salt by the ton for use in hospitals, veterinary medicine, and dentistry. This article will explain the history behind ketamine’s synthesis; its chemical structure; and the way a lab originally made the molecule. ....