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Novel immunotherapy boosts long-term stroke recovery in mice

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IMAGE: These images show how regulatory T cells (Treg cells) boost the ability of microglia cells to promote the regeneration of the brain s white matter (right), compared to a sample not.
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Credit: Xiaoming Hu/University of Pittsburgh
PITTSBURGH, May 19, 2021 - Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is over, University of Pittsburgh School of Medicine neurologists found.
The study, published today in the journal
Immunity, demonstrated that a population of specialized immune cells, called regulatory T (Treg) cells, serve as tissue repair engineers to promote functional recovery after stroke. Boosting Treg cells using an antibody complex treatment, originally designed as a therapy after transplantation and for diabetes, improved behavioral and cognitive function ....

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Novel Immunotherapy Boosts Long-Term Stroke Recovery in Mice

Novel Immunotherapy Boosts Long-Term Stroke Recovery in Mice
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Cell reprogramming could aid spinal cord injury recovery

Credit: Chris Thelen, Freelance Photographer
Cells called astrocytes normally support our neurons, and now scientists are working to reprogram the star-shaped cells into neurons that help reconnect the brain and body after a spinal cord injury.
We are at the stage of optimization. We know this reprogramming is feasible and we can do it, says Dr. Hedong Li, molecular neuroscientist in the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia.
Right now the state of really the entire field is: How do we make this a feasible approach? he says. How do we make this optimal in order to translate this into a clinic so it can lead to functional recovery following a spinal cord injury, brain injury, Alzheimer s, and all kinds of neurodegenerative disease, he says. We have a lot to do. ....

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