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Epigenomic landscape and 3D genome structure in pediatric high-grade glioma

Pediatric high-grade gliomas (pHGGs), including glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), are morbid brain tumors. Even with treatment survival is poor, making pHGG the number one cause of cancer death in children. Up to 80% of DIPGs harbor a somatic missense mutation in genes encoding histone H3. To investigate whether H3K27M is associated with distinct chromatin structure that alters transcription regulation, we generated the first high-resolution Hi-C maps of pHGG cell lines and tumor tissue. By integrating transcriptome (RNA-seq), enhancer landscape (ChIP-seq), genome structure (Hi-C), and chromatin accessibility (ATAC-seq) datasets from H3K27M and wild-type specimens, we identified tumor-specific enhancers and regulatory networks for known oncogenes. We identified genomic structural variations that lead to potential enhancer hijacking and gene coamplification, including A2M , JAG2 , and FLRT1 . Together, our results imply three-dimensional genome a ....

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Global High Resolution Melting Analysis Market Comprehensive aspect, Industry Insights and Technical Analysis 2021-2027 – KSU


Secondary Research, Primary Research, Company Share Analysis, Model ( including Macro-monetary pointers, Demographic information, and Industry pointers: Expenditure, foundation, area development, and offices ), Research Limitations and Revenue Based Modeling. Organization share examination is utilized to determine the size of the worldwide market. Just as an investigation of incomes of organizations for the last three to five years likewise gives the base to determine the market size and Shares (2021-2027 ) and its development rate. also, representing the High Resolution Melting Analysis Market Factor Analysis- 
Porter’s Five Forces, Supply/Value Chain, PESTEL analysis, CAGR value, product offerings, company landscape analysis, Market Entropy, CAPEX cycle, COGS Analysis, EBITDA analysis, Patent/Trademark Analysis, and Post COVID Impact Analysis. Key Leading Players having extreme Growth Rate in last Few decades included  ....

United States , Hong Kong , Guinea Bissau , El Salvador , United Arab Emirates , Dominican Republic , Costa Rica , Saudi Arabia , United Kingdom , South Korea , Trinidad And Tobago , Republic Of , South Africa , Kapa Biosystems , Asia Pacific , Manufacturing Base Distribution , Company Share Analysis , Company Details , Key Research Techniques , Our Research Analyst , Company Production Revenue , Research Limitations , Syndicate Research , Idaho Technology Inc , Company Overview , Syndicate Market Research ,