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New device accelerates transdermal penetration of drug molecules and extraction of interstitial fluid


New device accelerates transdermal penetration of drug molecules and extraction of interstitial fluid
A pain-free, organic and biodegradable drug delivery patch may be on the horizon for home health care patients soon.
Researchers from Tohoku University have developed a biobattery-powered device capable of both delivering large molecule pharmaceuticals across the skin barrier and extracting interstitial fluid for diagnostic purposes.
They published their approach online on Jan. 28 in
Nature Communications.
The team, led by corresponding author Matsuhiko Nishizawa, a professor in the Department of Finemechanics in the Graduate School of Engineering at Tohoku University, developed a microneedle array smaller than a pinky nail. The microneedles are porous, acting as interconnected conduits to either inject or extract fluid, including the large molecules of vaccines or even insulin. ....

Matsuhiko Nishizawa , Emily Henderson , School Of Engineering , Department Of Finemechanics , Nature Communications , School Of Engineering At Tohoku University , Tohoku University , Graduate School , Study Corresponding Author , Drug Delivery , Health Care , எமிலி ஹென்டர்சன் , பள்ளி ஆஃப் பொறியியல் , இயற்கை தகவல்தொடர்புகள் , பள்ளி ஆஃப் பொறியியல் இல் தோஹோக்கு பல்கலைக்கழகம் , தோஹோக்கு பல்கலைக்கழகம் , பட்டதாரி பள்ளி , மருந்து டெலிவரி , ஆரோக்கியம் பராமரிப்பு ,

Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer's


Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer’s
Loss of smell or olfactory dysfunction is an early indication of the neurodegenerative Alzheimer s disease (AD) and appears in approximately 90% of all patients. While loss of smell is a major symptom, patients with AD are only unable to recognize specific odors and do not completely lose their sense of smell; this suggests a possible region-specific involvement of the olfactive center in the brain.
Amyloid β (Aβ), a toxic protein that accumulates in the brain is a known contributing factor in AD pathogenesis and is also present in the olfactory system that controls the sense of smell. However, the pathology and mechanisms of AD-specific olfactory dysfunction involving olfactory sensory neurons (OSNs) remain unclear. ....

Emily Henderson , Alzheimer Research , Professor Cheil Moon , Alzheimer 39s Disease , Mouse Model , எமிலி ஹென்டர்சன் , முதுமறதி ஆராய்ச்சி , சுட்டி மாதிரி ,