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New drug combo shows early potential to treat pancreatic cancer

The new therapy, which is a combination of three drugs that help boost the body s immune defences against tumors, is likely to enter clinical trials later this year. ....

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Global Immuno-Oncology Diagnostics Markets, 2021-2025: Checkpoint Assays, Cytokine Assays, Genomic Germline, Genomic Tumour, Tumor Microenviroment

4.3.2 Shifting Role of Diagnostics
4.3.3 Multiplexing and Foundation One
4.3.4 The Disruption Dynamic
4.3.6 The Next Five Years
5. Cancer Immuno-Oncology Diagnostics Recent Developments
5.1 Recent Developments - Importance and How to Use This Section
5.1.1 Importance of These Developments
5.1.2 How to Use This Section
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FDA Approves CDx for Trastuzumab
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ArcherDx partners with AstraZeneca for Immuno-Oncology
Germline Results Guides Precision Therapy
Agilent PD-L1 Assay Gets FDA Approval
Bayer, OrigiMed Form Companion Diagnostic Development Alliance
Bio-Me to Develop Microbiome Biomarker Test for Cancer Immunotherapy
SkylineDx, BioInvent Collaborate to Characterize Predictive Immunological ....

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New Target for Pancreatic Cancer Therapy Identified

New Target for Pancreatic Cancer Therapy Identified
January 25, 2021
[Source: Dr Microbe/Getty Images]
Researchers at Queen Mary University of London have identified a new therapy target, a protein called CEACAM7, that could be used to help treat pancreatic cancer.
The team managed to create a CAR T cell therapy using this target that was able to kill pancreatic cancer cells in the lab and also in a mouse model.
Pancreatic cancer affects around 57,600 adults a year in the U.S. and is difficult to diagnose and treat. It has a poor prognosis and is the fourth leading cause of cancer death with a 5-year survival rate of only 9%. Most (around 85-90%) pancreatic cancers are adenocarcinomas, such as pancreatic ductal adenocarcinoma, whereas a much smaller percentage are less aggressive, neuroendocrine tumors. ....

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"CEACAM7": Novel protein may improve safety of therapy for pancreatic cancer

CEACAM7 : Novel protein may improve safety of therapy for pancreatic cancer
This is an exciting development, said John Marshall, Professor from Queen Mary University of London
Saturday January 23, 2021 12:45 PM, IANS
London: Researchers have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer.
Using this protein as a target, the team successfully created a CAR T cell therapy a type of immunotherapy that killed pancreatic cancer cells in a pre-clinical model.
This is an exciting development, said John Marshall, Professor from Queen Mary University of London.
Finding that CEACAM7 allows us to kill pancreatic cancer cells specifically with CAR T cells while having no significant toxicity in non-tumour tissues, gives us hope that this strategy could be effective in the future, Marshall added. ....

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