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Scientists discover role of lncRNA in regulating Hippo signaling via phase separation


Zhejiang University
Membraneless compartments which are formed via active liquid-liquid phase separation (LLPS) or condensation are crucial for spatiotemporal regulation of cellular functions. LLPS is driven by multivalent, weak interactions, involving intrinsically disordered regions (IDR), folded protein, and scaffolding DNA or RNA molecules. Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. By coordinating with RNA-binding proteins (RBP), RNAs, such as NEAT1, also play crucial roles in triggering LLPS in a concentration- or structure-dependent manner.
Recent studies demonstrate that lncRNAs play a vital role in mediating intracellular signaling pathways. Previous research by Prof. LIN Aifu from the Zhejiang University College of Life Sciences reveals that LINK-A, a membrane phospholipid PIP3-binding lncRNA, can facilitate AKT-PIP3 interaction and consequent AKT enzymatic ....

Zhejiang University , Cell Research , Zhejiang University College Of Life Sciences , Zhejiang University College , Life Sciences , Phosphatidic Acid Binding , Phase Separation , Promote Oncogenic , Large Tumor Suppressor Kinase , ஜெஜியாங் பல்கலைக்கழகம் , செல் ஆராய்ச்சி , ஜெஜியாங் பல்கலைக்கழகம் கல்லூரி ஆஃப் வாழ்க்கை அறிவியல் , ஜெஜியாங் பல்கலைக்கழகம் கல்லூரி , வாழ்க்கை அறிவியல் , கட்டம் பிரிப்பு ,