Zhejiang University
Membraneless compartments which are formed via active liquid-liquid phase separation (LLPS) or condensation are crucial for spatiotemporal regulation of cellular functions. LLPS is driven by multivalent, weak interactions, involving intrinsically disordered regions (IDR), folded protein, and scaffolding DNA or RNA molecules. Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. By coordinating with RNA-binding proteins (RBP), RNAs, such as NEAT1, also play crucial roles in triggering LLPS in a concentration- or structure-dependent manner.
Recent studies demonstrate that lncRNAs play a vital role in mediating intracellular signaling pathways. Previous research by Prof. LIN Aifu from the Zhejiang University College of Life Sciences reveals that LINK-A, a membrane phospholipid PIP3-binding lncRNA, can facilitate AKT-PIP3 interaction and consequent AKT enzymatic activati
Zhejiang-university
Cell-research
Zhejiang-university-college-of-life-sciences
Zhejiang-university-college
Life-sciences
Phosphatidic-acid-binding
Phase-separation
Promote-oncogenic
Large-tumor-suppressor-kinase
ஜெஜியாங்-பல்கலைக்கழகம்
செல்-ஆராய்ச்சி