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Novel malaria vaccine candidate gives strong, lasting protection


Malaria parasite. Photo: SENSISEEDSTwo United States (U.S.) Phase 1 clinical trials of a novel candidate malaria vaccine have found that the regimen conferred unprecedented high levels of durable protection when volunteers were later exposed to disease-causing malaria parasites.
According to the study published, yesterday, in the journal Nature, by A. Mwakingwe-Omari et al and titled ‘Two chemo-attenuated PfSPZ malaria vaccines induce sterile hepatic immunity’, the vaccine combines live parasites with either of two widely used antimalarial drugs- an approach termed chemoprophylaxis vaccination.
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The researchers said a Phase 2 clinical trial of the vaccine is now underway in Mali, a malaria-endemic country. If the approach proves successful there, chemoprophylaxis vaccination, or CVac, potentially could help reverse the stalled decline of global malaria. Currently, there is no vaccine in widespread use for the mosquito-transmit ....

United States , Patricke Duffy , Stephenl Hoffman , Clinical Centre In Bethesda , United States National Institutes Of Health , National Institute Of Allergy , Sanaria Inc , United States National Institutes , Clinical Centre , Infectious Diseases , South American , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது மாநிலங்களில் தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தேசிய நிறுவனம் ஆஃப் ஒவ்வாமை , ஒன்றுபட்டது மாநிலங்களில் தேசிய நிறுவனங்கள் , மருத்துவ மையம் , தொற்று நோய்கள் , தெற்கு அமெரிக்கன் ,