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Defining Alzheimer's: Should Cognitively Unimpaired People Be Included?


How do you define Alzheimer s disease?
The International Working Group (IWG) argued that for everyday clinical use, a biological definition alone the basis of the National Institute on Aging and the Alzheimer s Association (NIA-AA) framework is not enough.
Cognitively unimpaired individuals can have biomarker evidence of both amyloid beta and tau pathology but may not develop clinical signs of Alzheimer s disease in their lifetime, said Bruno Dubois, MD, of Assistance Publique-Hôpitaux de Paris in France, and a group of 19 other IWG physicians.
Furthermore, a positive Alzheimer s disease pattern of biomarkers can be observed in other brain diseases in which Alzheimer s disease pathology is present as a comorbidity, the team wrote in the ....

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