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Moderna's mRNA technology could help in the decades-long search for an HIV vaccine


Moderna s partnership will build on a new and unproven vaccine approach
William Schief, an immunology professor at Scripps Research and vaccine design director of the International AIDS Vaccine Initiative, presented Moderna s investors with unpublished data from an HIV vaccine trial presented at a virtual AIDS research conference in February.
The trial, which started in 2018, was conducted with 48 HIV-negative adults, and will serve as preliminary basis off which Moderna and its collaborators will further study and test a vaccine approach targeting broadly neutralizing antibodies. Subjects were given either a low or high dose of the protein-based vaccine candidate, which was designed to activate certain naive B cells of the immune system. ....

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Trained Dogs Sniff Out COVID-19-Positive Samples With 96% Accuracy


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Many long for a return to a post-pandemic “normal,” which, for some, may entail concerts, travel, and large gatherings. But how to keep safe amid these potential public health risks?
One possibility, according to a new study, is dogs. A proof-of-concept investigation published today in the journal PLOS ONE suggests that specially trained detection dogs can sniff out COVID-19-positive samples with 96% accuracy.
“This is not a simple thing we’re asking the dogs to do,” says Cynthia Otto, senior author on the work and director of the University of Pennsylvania School of Veterinary Medicine Working Dog Center. “Dogs have to be specific about detecting the odor of the infection, but they also have to generalize across the background odors of different people: men and women, adults and children, people of different ethnicities and geographies.” ....

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The FINANCIAL - With impressive accuracy, dogs can sniff out coronavirus


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The FINANCIAL  Many long for a return to a post-pandemic “normal,” which, for some, may entail concerts, travel, and large gatherings. But how to keep safe amid these potential public health risks?
According to University of Pennsylvania, one possibility, according to a new study, is dogs. A proof-of-concept investigation published today in the journal PLOS ONE suggests that specially trained detection dogs can sniff out COVID-19-positive samples with 96% accuracy.
“This is not a simple thing we’re asking the dogs to do,” says Cynthia Otto, senior author on the work and director of the University of Pennsylvania School of Veterinary Medicine Working Dog Center. “Dogs have to be specific about detecting the odor of the infection, but they also have to generalize across the background odors of different people: men and women, adults and children, people of different ethnicities and geographies.” ....

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A New HIV Vaccine Could Be One of Moderna's Next MRNA Success Story


Photo by CHANDAN KHANNA/AFP via Getty Images
Moderna s mRNA tech could change the game in the decades-long effort to develop an HIV vaccine.
The company said it expects to begin two vaccine trials in humans by the end of 2021.
While excited by the prospect, HIV researchers caution there s a long road ahead for mRNA vaccines.
Moderna s investor presentation on Wednesday showcased the Massachusetts-based biotech s efforts to develop vaccines against HIV and eight other infectious diseases.
The company s mRNA technology, which has built upon decades of research, will now contribute to the long frustrated effort to contain the global HIV/AIDS epidemic. ....

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