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MD Anderson and Blueprint Medicines Announce Strategic Collaboration to Accelerate BLU-222 Development


Published: Jul 28, 2021
 
HOUSTON and CAMBRIDGE, Mass., July 28, 2021 /PRNewswire/  The University of Texas MD Anderson Cancer Center and Blueprint Medicines Corporation (NASDAQ: BPMC) today announced a three-year strategic research collaboration focused on accelerating development of BLU-222, an investigational precision therapy designed to target cyclin-dependent kinase 2 (CDK2).
The collaboration brings together MD Anderson translational research scientists, the drug development capabilities of MD Anderson s Therapeutics Discovery division and Blueprint Medicines precision therapy pipeline and expertise. The teams seek to characterize the range of cancer types susceptible to treatment with a selective CDK2 inhibitor, advance BLU-222 mono- and combination-therapy strategies with the potential to maximize patient benefit, and identify novel biomarkers that may better predict treatment response and optimize patient selection. ....

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NK cells with bispecific antibody show activity against lymphoma cells


Date Time
NK cells with bispecific antibody show activity against lymphoma cells
Cytokine-activated natural killer (NK) cells derived from donated umbilical cord blood, combined with an investigational bispecific antibody targeting CD16a and CD30 known as AFM13, displayed potent anti-tumor activity against CD30+ lymphoma cells, according to a new preclinical study from researchers at The University of Texas MD Anderson Cancer Center.
The findings were published today in Clinical Cancer Research, a journal of the American Association for Cancer Research. These results led to the launch of a Phase I clinical trial to evaluate the combination of cord blood-derived NK cells (cbNK cells) with AFM13 as an experimental cell-based immunotherapy in patients with CD30+ lymphoma. ....

United States , Katy Rezvani , Pinaki Banerjee , American Association For Cancer Research , University Of Texas Md Anderson Cancer Center , National Institute Of Health , National Cancer Institute , Md Anderson Cord Blood Bank , Clinical Cancer Research , American Association , Stem Cell Transplantation , Cord Blood Bank , Cancer Research , National Institute , Institutional Conflict , Pinterest Management , Md Anderson Cancer Center , University Of Texas , National Cancer Institute , Conflict Of Interest , Cancer Research , Clinical Trial , Umbilical Cord , Cell Therapies , ஒன்றுபட்டது மாநிலங்களில் , பினாக்கி பானர்ஜி ,