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Frontiers | Emergence of Dengue 4 as Dominant Serotype During 2017 Outbreak in South India and Associated Cytokine Expression Profile

Dengue virus infection is prevalent in tropical and sub-tropical regions of the world, which is fatal if untreated symptomatically. Emergence of new genotype within serotypes led to enhanced severity. The objective of the study is to identify the molecular characteristics of the DENV circulated during 2017 outbreak in Tamil Nadu, India and, to investigate the role of inflammatory cytokines in different ‘serotypes’ and in ‘dengue severity’. A total of 135 suspected samples were tested for DENV infection using IgM, IgG and qPCR assay; where 76 samples were positive for DENV and analysed for twelve inflammatory cytokines using ELISA. Serotyping shows 14 DENV-1, 22 DENV-2, 7 DENV-3 and 33 DENV-4, where DENV-4 was predominant. Among seventy-six, forty-two isolates were successfully sequenced for C-prM region and grouped. A lineage shift was observed in DENV-4 genotype. Irrespective of serotypes, IFNγ was significantly elevated than control and in primary infection indicating its ro ....

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Obituary: George A. Paulin

He was born to the late Arthur and Jean Paulin in Berlin, N.H. on March 1, 1948.
George graduated From Berlin High School in 1967, and proudly served his country in the Navy.
George is survived by his son Matthew Paulin and his long-time girlfriend Julia of Orlando Fla., daughter Adrienne McDougall of Halifax, Mass., son-in-law Christopher and their children, Ruby McDougall and William Bryant, and by the mother of his children Donna Paulin.
He is also survived by his sister Louise Sherman of Brockton, Mass. and three nieces Candace, Heidi and Erika. He is predeceased by his girlfriend Linda Joy who is survived by her children Chantal, Sarah, and Joseph. ....

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Richard Luden Long | News, Sports, Jobs

May 12, 2021
Richard Luden Long, 56, of Harrisburg and Lewistown Pa., passed away suddenly on May 2, 2021. He was born in Lewistown, Pa. to Walter A. and Nancy Byler Long. Richard was preceded in death by his mother Nancy Byler Long; brother Walter “Pete” Long Jr.; a very special nephew, Zachary Alan Long, and “Aunt Sissy” Pauline Shover. Richard was the co-owner of “Darn That Junk Hauling and Cleaning Services” and “Gazette Antiques.” He currently worked at Keystone Area Goodwill Services in the capacity of Assistant to Custodial Services. Richard proudly served his country in the United States Air Force, where he was a food service specialist at Dover Air Force Base in Dover, Del. ....

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California COVID Regulations Force Change to TYR 18 & U Spring Cup

California COVID Regulations Force Change to TYR 18 & U Spring Cup
swimmingworldmagazine.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from swimmingworldmagazine.com Daily Mail and Mail on Sunday newspapers.

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