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Africans begin to take the reins of research into their own genomes


(Graphic) K. Franklin/Science
Those databases will illuminate studies of human variation worldwide, in part because the great genomic diversity in Africans can uncover spurious links to medical conditions, explains Concepcion Nierras, an NIH Common Fund geneticist. For example, in Europeans a rare variant of a gene for a low-density lipoprotein that contributes to high cholesterol seemed to raise the risk of heart disease. But Fatumo and his colleagues found that among Africans, the variant was common even in those who did not have heart disease, suggesting it may not have clinical relevance. The 
Nature paper uncovered 54 such variants that now need re-evaluation. ....

United States , Democratic Republic Of The Congo , University Of Cape Town , Western Cape , South Africa , University Of Botswana , South East , Baden Wuberg , United Kingdom , Abuja Federal Capital Territory , South African , Francis Collins , Lesedi Williams , Iiruka Okeke , Elizabeth Pennisi , Concepcion Nierras , Clement Adebamowo , Steven Salzberg , Ananyo Choudhury , Erisa Mwaka Sabakaki , Stefan Jansen , Segun Fatumo , Neil Hanchard , Richard Cooper , Tesfaye Mersha , Sarah Tishkoff ,

Looking back at 20 years of human genome sequencing


Holly Gramazio/Flickr
This week we’re dedicating the whole show to the 20th anniversary of the publication of the human genome. Today, about 30 million people have had their genomes sequenced. This remarkable progress has brought with it issues of data sharing, privacy, and inequality.
Host Sarah Crespi spoke with a number of researchers about the state of genome science, starting with Yaniv Erlich, from the Efi Arazi School of Computer Science and CEO of Eleven Biotherapeutics, who talks about privacy in the age of easily obtainable genomes.
Next up Charles Rotimi, director of the Center for Research on Genomics and Global Health at the National Human Genome Research Institute, discusses diversity or lack thereof in the field and what it means for the kinds of research that happens. ....

Dorothy Roberts , Sarah Crespi , Yaniv Erlich , Charles Rotimi , Research On Genomics , Efi Arazi School Of Computer Science , Global Health , National Human Genome Research Institute , University Of Pennsylvania , Efi Arazi School , Computer Science , டோரதி ராபர்ட்ஸ் , சாரா கிரேஸிபி , ஆராய்ச்சி ஆன் மரபியல் , எஃபி அராஸி பள்ளி ஆஃப் கணினி அறிவியல் , உலகளாவிய ஆரோக்கியம் , தேசிய மனிதன் மரபணு ஆராய்ச்சி நிறுவனம் , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , எஃபி அராஸி பள்ளி , கணினி அறிவியல் ,