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Bispecific antibodies targeting mutant RAS neoantigens

Diabodies see the unseeable
RAS oncogene mutations are common in various cancers, controlling their growth and survival. Targeting mutant RAS proteins with antibodies has been unsuccessful due to low surface expression, even when targeting mutant RAS peptides presented via HLA on the surface of cancer cells. Douglass
et al. used phage display to generate single-chain variable fragments (scFvs) specific for mutant RAS peptide-HLA complexes. The authors tested various bispecific, T cell–engaging antibody formulations, finding that single-chain diabodies (scDbs) combining the aforementioned scFv with an anti-CD3 scFv were able to induce T cell activation and subsequent killing of tumor cells expressing mutant RAS peptide-HLA complexes. This scDb approach opens the door for antibody-based therapies against mutant neoantigens expressed at very low levels on the surface of cancer cells. ....

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Single Domain Antibody Platforms Market is expected to witness an impressive CAGR of around 10% during 2020 to 2030

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NEW YORK, Dec. 11, 2020 /PRNewswire/ Monoclonal antibodies are highly efficient as therapeutics against viral infections, immune diseases, and cancer. However, they are large in size and unable to access some epitopes, besides the production cost being high. Hence, single-domain antibodies (sdAbs) is an alternative for monoclonal due to larger number of accessible epitopes, smaller size, relatively low production costs, and potent inhibitors against immune and viral diseases. Currently, single-domain antibodies are being developed against a number of viruses, including influenza viruses, HIV, hepatitis C virus (HCV), enteric viruses, and respiratory syncytial virus (RSV).
Technological advancements in single-domain antibody platforms such as production of bispecific and multi-specific antibodies to target particular antigens during therapeutic developments are some other factors that will boost the growth of the single-domain antibody platforms market. ....

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