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Researchers Show How COVID-19 Virus Triggers Immune Signaling "Storm"


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NEW YORK, May 14, 2021 /PRNewswire/ Researchers have discovered new ways in which the COVID-19 virus causes human immune cells to overreact, a deadly part of the disease.
Led by researchers from NYU Grossman School of Medicine and the Perlmutter Cancer Center at NYU Langone Health, the new study found that SARS-CoV-2, the pandemic virus, interacts with specific proteins on immune cells, causing these cells to release abnormally high levels of immune signaling proteins called cytokines (a cytokine storm ). These cytokines, in turn, cause fluid buildup in the lungs and makes it hard to breathe. ....

Jun Wang , Peng Lin , Ming Zhou , Ruochen Zang , Shuai Zhao , Yue Liu , Kamal Khanna , Zemin Zhang , Hongzhen Tang , Tao Wang , Xufeng Chen , Gomez Castro , Broc Mccune , Xianwen Ren , James Zhu , Payal Damani Yokota , Tina Tianjiao Su , Triantafyllia Karakousi , Erita Chen , Shumin Jin , Iannis Aifantis , Maria Florencia , Maria Kaczmarek , Qiao Lu , Stephen Yeung , Maudry Laurent Rolle ,

Scientists develop a new method to study the molecular characteristics of T cells


Scientists develop a new method to study the molecular characteristics of T cells
UT Southwestern scientists have developed a new method to study the molecular characteristics of T cells, critical immune cells that recognize and attack invaders in the body such as viruses, bacteria, and cancer.
The approach, described today in the journal
Nature Methods, enables researchers to more easily analyze the roles of T cell receptors (TCRs) - the molecules on the surfaces of T cells that are responsible for recognizing pathogens.
This could lead to a better understanding of how T cells work as well as new ways to harness T cells to fight disease. ....

David Gerber , Tao Wang , Todd Aguilera , Emily Henderson , Quantitative Biomedical Research Center , Haroldc Simmons Comprehensive Cancer Center , Nature Methods , Comprehensive Cancer Center , Immune Response , டேவிட் கெர்பர் , தாவோ வாங் , எமிலி ஹென்டர்சன் , அளவு உயிர் மருத்துவ ஆராய்ச்சி மையம் , இயற்கை முறைகள் , விரிவான புற்றுநோய் மையம் , நோயெதிர்ப்பு சிகிச்சை , நோய் எதிர்ப்பு சக்தி பதில் ,

Advancing the study of T cells to improve immunotherapy


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IMAGE: The above illustration, in the center, shows activation of T cell immune response with the interaction of MHC-II (red) with the T cell receptor (TCR, blue), and also CD4 (light.
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Credit: Art purchased from Alamy and modified by Dr. Tao Wang.
DALLAS - Jan. 6, 2020 - UT Southwestern scientists have developed a new method to study the molecular characteristics of T cells, critical immune cells that recognize and attack invaders in the body such as viruses, bacteria, and cancer.
The approach, described today in the journal
Nature Methods, enables researchers to more easily analyze the roles of T cell receptors (TCRs) - the molecules on the surfaces of T cells that are responsible for recognizing pathogens. ....

United States , Southern Methodist University , David Gerber , Danyi Xiong , Hongyu Liu , Xinlei Wang , Tao Wang , Todd Aguilera , Quantitative Biomedical Research Center , National Institutes Of Health , Haroldc Simmons Comprehensive Cancer Center , Research Institute Of Texas , Nature Methods , Comprehensive Cancer Center , Southern Methodist , National Institutes , Cancer Prevention , Research Institute , ஒன்றுபட்டது மாநிலங்களில் , தெற்கு முறை பல்கலைக்கழகம் , டேவிட் கெர்பர் , தாவோ வாங் , அளவு உயிர் மருத்துவ ஆராய்ச்சி மையம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ஆராய்ச்சி நிறுவனம் ஆஃப் டெக்சாஸ் , இயற்கை முறைகள் ,