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Frontiers | A Novel Probable Pathogenic PSEN2 Mutation p.Phe369Ser Associated With Early-Onset Alzheimer's Disease in a Chinese Han Family: A Case Report

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
The pathogenesis of Alzheimer s disease is complex, and early-onset Alzheimer s disease (EOAD) is mostly influenced by genetic factors. Presenilin-1, presenilin-2 (PSEN2), and amyloid precursor protein are currently known as the three main causative genes for autosomal dominant EOAD, with the PSEN2 mutation being the rarest. In this study, we reported a 56-year-old Chinese Han proband who presented with prominent progressive amnesia, aphasia, executive function impairment, and depression 5 years ago. The 3-year follow-up showed that the patient experienced progressive brain atrophy displayed on magnetic resonance imaging (MRI) and dramatic cognitive decline assessed by neuropsychological evaluation. This patient was clinically diagnosed as EOAD based on established criteria. A heterozygous variant (NM 000447.2: c.1106T>C) of PSEN2 was identified for the first time in this patient a ....

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Cognitive Clock Predicts Brain Health

Brain age forecasts outcomes better than chronological age ....

United States , Rush University Medical Center , Judy George , Alzheimers Dement , Patricia Boyle , Chicago Health , Rush Memory , Aging Project , Religious Orders Study , Mini Mental State Exam , Medpage Today , Mild Cognitive Impairment , Alzheimer 039s Disease , Cognitive Decline , Cognitive Impairment , ஒன்றுபட்டது மாநிலங்களில் , அவசரம் பல்கலைக்கழகம் மருத்துவ மையம் , ஜூடி ஜார்ஜ் , அல்சைமர் டெமென்ட் , பாட்ரிசியா பாயில் , சிகாகோ ஆரோக்கியம் , அவசரம் நினைவு , மத ஆர்டர்ஸ் படிப்பு , மினி மன நிலை தேர்வு , லேசான அறிவாற்றல் குறைபாடு , அறிவாற்றல் குறைபாடு ,

Eisai Presents Breadth of Data Across Neurology Portfolio, Including Alzheimer's Disease, Insomnia and Epilepsy

Eisai Presents Breadth of Data Across Neurology Portfolio, Including Alzheimer s Disease, Insomnia and Epilepsy
Twenty-one presentations featuring data and information on investigational lecanemab in early Alzheimer s disease, DAYVIGO® (lemborexant) CIV in insomnia, FYCOMPA® (perampanel) CIII in epilepsy and investigational lorcaserin in Dravet Syndrome
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WOODCLIFF LAKE, N.J., April 16, 2021 /PRNewswire/ Eisai Inc., the U.S. pharmaceutical subsidiary of Eisai Co., Ltd., announced today that data from the company s deep neurology pipeline and portfolio, including Alzheimer s disease, insomnia and epilepsy, will be presented at the 73
rd Annual Meeting of the American Academy of Neurology (AAN), taking place virtually from April 17-22, 2021. ....

United States , New Jersey , North Carolina , Gary Zammit , Shau Yu Lynch , Alzheimers Dement , Ryan Husni , Genevieve Meier , Carmen Castrillo Viguera , Craig Chepke , Ivan Cheung , Chris Vancheri , Michael Irizarry , Russell Rosenberg , Rakeh Jain , Rohit Shankar , National Institute On , Biogen Inc , Prnewswire Eisai Inc , European Union , Us Drug Enforcement Administration , Eisai Tsukuba Research Laboratories , Meeting Of The American Academy Neurology , National Institutes Of Health , Epilepsy Foundation , Drug Administration ,