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The study, published in the leading journal Circulation Research, found that long-term training in both horses and mice caused a reduction in key proteins, known as ion channels, that control AV node conduction. The expression and activity of the ion channels were then investigated in detail in mice that followed a program which modelled long-term exercise training to build their fitness. The mice were used to explore mechanisms underlying heart block in detail using approaches that would not be possible in racehorses. Training-induced heart block and underlying ion channel changes were reversible when the exercise was stopped or when mice were given a compound known as an anti-microRNA. ....
Researchers identify heart block cause in athletes While heart block is benign for most people, it can be a precursor to more serious heart problems. 23 June, 2021 23:01 Why some endurance athletes experience a heart rhythm disturbance called heart block has been identified by researchers using animal models. The University of Manchester-led study found that long-term exercise in retired racehorses – the best available model of the athlete’s heart – and in mice, triggered molecular changes in a part of the heart known as the atrioventricular (or AV) node. Despite well-recognised cardiovascular benefits, sustained endurance exercise in athletes, footballers and other sportspeople can lead to the development of abnormal heart rhythms – known as cardiac arrhythmias, including heart block. ....
Study identifies heart block cause in athletes miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.